ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuit

APOL1 risk variants are associated with increased risk of kidney disease in patients of African ancestry, but not all individuals with the APOL1 high-risk genotype develop kidney disease. As APOL1 gene expression correlates closely with the degree of kidney cell injury in both cell and animal models...

Descripción completa

Detalles Bibliográficos
Autores principales: Riella, Cristian V., McNulty, Michelle, Ribas, Guilherme T., Tattersfield, Calum F., Perez-Gill, Chandra, Eichinger, Felix, Kelly, Jessica, Chun, Justin, Subramanian, Balajikarthick, Guizelini, Dieval, Alper, Seth L., Pollak, Martin R., Sampson, Matthew G., Friedman, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636950/
https://www.ncbi.nlm.nih.gov/pubmed/36282916
http://dx.doi.org/10.1073/pnas.2210150119

Ejemplares similares

Ejemplares similares