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Understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory

The last decade has seen significant progress in identifying sleep mechanisms that support cognition. Most of these studies focus on the link between electrophysiological events of the central nervous system during sleep and improvements in different cognitive domains, while the dynamic shifts of th...

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Autores principales: Chen, Pin-Chun, Zhang, Jing, Thayer, Julian F., Mednick, Sara C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636982/
https://www.ncbi.nlm.nih.gov/pubmed/36279428
http://dx.doi.org/10.1073/pnas.2123417119
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author Chen, Pin-Chun
Zhang, Jing
Thayer, Julian F.
Mednick, Sara C.
author_facet Chen, Pin-Chun
Zhang, Jing
Thayer, Julian F.
Mednick, Sara C.
author_sort Chen, Pin-Chun
collection PubMed
description The last decade has seen significant progress in identifying sleep mechanisms that support cognition. Most of these studies focus on the link between electrophysiological events of the central nervous system during sleep and improvements in different cognitive domains, while the dynamic shifts of the autonomic nervous system across sleep have been largely overlooked. Recent studies, however, have identified significant contributions of autonomic inputs during sleep to cognition. Yet, there remain considerable gaps in understanding how central and autonomic systems work together during sleep to facilitate cognitive improvement. In this article we examine the evidence for the independent and interactive roles of central and autonomic activities during sleep and wake in cognitive processing. We specifically focus on the prefrontal–subcortical structures supporting working memory and mechanisms underlying the formation of hippocampal-dependent episodic memory. Our Slow Oscillation Switch Model identifies separate and competing underlying mechanisms supporting the two memory domains at the synaptic, systems, and behavioral levels. We propose that sleep is a competitive arena in which both memory domains vie for limited resources, experimentally demonstrated when boosting one system leads to a functional trade-off in electrophysiological and behavioral outcomes. As these findings inevitably lead to further questions, we suggest areas of future research to better understand how the brain and body interact to support a wide range of cognitive domains during a single sleep episode.
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spelling pubmed-96369822022-11-06 Understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory Chen, Pin-Chun Zhang, Jing Thayer, Julian F. Mednick, Sara C. Proc Natl Acad Sci U S A Perspective The last decade has seen significant progress in identifying sleep mechanisms that support cognition. Most of these studies focus on the link between electrophysiological events of the central nervous system during sleep and improvements in different cognitive domains, while the dynamic shifts of the autonomic nervous system across sleep have been largely overlooked. Recent studies, however, have identified significant contributions of autonomic inputs during sleep to cognition. Yet, there remain considerable gaps in understanding how central and autonomic systems work together during sleep to facilitate cognitive improvement. In this article we examine the evidence for the independent and interactive roles of central and autonomic activities during sleep and wake in cognitive processing. We specifically focus on the prefrontal–subcortical structures supporting working memory and mechanisms underlying the formation of hippocampal-dependent episodic memory. Our Slow Oscillation Switch Model identifies separate and competing underlying mechanisms supporting the two memory domains at the synaptic, systems, and behavioral levels. We propose that sleep is a competitive arena in which both memory domains vie for limited resources, experimentally demonstrated when boosting one system leads to a functional trade-off in electrophysiological and behavioral outcomes. As these findings inevitably lead to further questions, we suggest areas of future research to better understand how the brain and body interact to support a wide range of cognitive domains during a single sleep episode. National Academy of Sciences 2022-10-24 2022-11-01 /pmc/articles/PMC9636982/ /pubmed/36279428 http://dx.doi.org/10.1073/pnas.2123417119 Text en Copyright © 2022 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Perspective
Chen, Pin-Chun
Zhang, Jing
Thayer, Julian F.
Mednick, Sara C.
Understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory
title Understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory
title_full Understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory
title_fullStr Understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory
title_full_unstemmed Understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory
title_short Understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory
title_sort understanding the roles of central and autonomic activity during sleep in the improvement of working memory and episodic memory
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636982/
https://www.ncbi.nlm.nih.gov/pubmed/36279428
http://dx.doi.org/10.1073/pnas.2123417119
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