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miRNAs: The Key Regulator of COVID-19 Disease

As many parts of the world continue to fight the innumerable waves of COVID-19 infection, SARS-CoV-2 continues to sculpt its antigenic determinants to enhance its virulence and evolvability. Several vaccines were developed and used around the world, and oral antiviral medications are being developed...

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Autores principales: Hardin, Leyla Tahrani, Xiao, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637033/
https://www.ncbi.nlm.nih.gov/pubmed/36345541
http://dx.doi.org/10.1155/2022/1645366
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author Hardin, Leyla Tahrani
Xiao, Nan
author_facet Hardin, Leyla Tahrani
Xiao, Nan
author_sort Hardin, Leyla Tahrani
collection PubMed
description As many parts of the world continue to fight the innumerable waves of COVID-19 infection, SARS-CoV-2 continues to sculpt its antigenic determinants to enhance its virulence and evolvability. Several vaccines were developed and used around the world, and oral antiviral medications are being developed against SARS-CoV-2. However, studies showed that the virus is mutating in line with the antibody's neutralization escape; thus, new therapeutic alternatives are solicited. We hereby review the key role that miRNAs can play as epigenetic mediators of the cross-talk between SARS-CoV-2 and the host cells. The limitations resulting from the “virus intelligence” to escape and antagonize the host miRNAs as well as the possible mechanisms that could be used in the viral evasion strategies are discussed. Lastly, we suggest new therapeutic approaches based on viral miRNAs.
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spelling pubmed-96370332022-11-06 miRNAs: The Key Regulator of COVID-19 Disease Hardin, Leyla Tahrani Xiao, Nan Int J Cell Biol Review Article As many parts of the world continue to fight the innumerable waves of COVID-19 infection, SARS-CoV-2 continues to sculpt its antigenic determinants to enhance its virulence and evolvability. Several vaccines were developed and used around the world, and oral antiviral medications are being developed against SARS-CoV-2. However, studies showed that the virus is mutating in line with the antibody's neutralization escape; thus, new therapeutic alternatives are solicited. We hereby review the key role that miRNAs can play as epigenetic mediators of the cross-talk between SARS-CoV-2 and the host cells. The limitations resulting from the “virus intelligence” to escape and antagonize the host miRNAs as well as the possible mechanisms that could be used in the viral evasion strategies are discussed. Lastly, we suggest new therapeutic approaches based on viral miRNAs. Hindawi 2022-10-29 /pmc/articles/PMC9637033/ /pubmed/36345541 http://dx.doi.org/10.1155/2022/1645366 Text en Copyright © 2022 Leyla Tahrani Hardin and Nan Xiao. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hardin, Leyla Tahrani
Xiao, Nan
miRNAs: The Key Regulator of COVID-19 Disease
title miRNAs: The Key Regulator of COVID-19 Disease
title_full miRNAs: The Key Regulator of COVID-19 Disease
title_fullStr miRNAs: The Key Regulator of COVID-19 Disease
title_full_unstemmed miRNAs: The Key Regulator of COVID-19 Disease
title_short miRNAs: The Key Regulator of COVID-19 Disease
title_sort mirnas: the key regulator of covid-19 disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637033/
https://www.ncbi.nlm.nih.gov/pubmed/36345541
http://dx.doi.org/10.1155/2022/1645366
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