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Effects of cancer-associated point mutations on the structure, function, and stability of isocitrate dehydrogenase 2

Mutations in isocitrate dehydrogenase (IDH) are frequently found in low-grade gliomas, secondary glioblastoma, chondrosarcoma, acute myeloid leukemias, and intrahepatic cholangiocarcinoma. However, the molecular mechanisms of how IDH2 mutations induce carcinogenesis remain unclear. Using overlapping...

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Detalles Bibliográficos
Autores principales:	Chen, Xiang, Yang, Peipei, Qiao, Yue, Ye, Fei, Wang, Zhipeng, Xu, Mengting, Han, Xiaowang, Song, Li, Wu, Yuehong, Ou, Wen-Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637083/ https://www.ncbi.nlm.nih.gov/pubmed/36335201 http://dx.doi.org/10.1038/s41598-022-23659-y

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