A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors

More and more evidence show that HK2 is closely related to tumors. But no pan-cancer analysis is available. This paper aimed to explore the potential roles of HK2 across thirty-three tumors based on the datasets of the cancer genome Atlas (TCGA) and gene expression omnibus. HK2 is highly expressed i...

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Autores principales: Li, Ruiqi, Mei, Shuchong, Ding, Qiang, Wang, Qingming, Yu, Li, Zi, Fuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637150/
https://www.ncbi.nlm.nih.gov/pubmed/36335239
http://dx.doi.org/10.1038/s41598-022-23598-8
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author Li, Ruiqi
Mei, Shuchong
Ding, Qiang
Wang, Qingming
Yu, Li
Zi, Fuming
author_facet Li, Ruiqi
Mei, Shuchong
Ding, Qiang
Wang, Qingming
Yu, Li
Zi, Fuming
author_sort Li, Ruiqi
collection PubMed
description More and more evidence show that HK2 is closely related to tumors. But no pan-cancer analysis is available. This paper aimed to explore the potential roles of HK2 across thirty-three tumors based on the datasets of the cancer genome Atlas (TCGA) and gene expression omnibus. HK2 is highly expressed in most tumors and related to the progression of some tumors. HK2 expression was associated with the infiltration of T follicular helper cells for the TCGA tumors of uveal melanoma, breast invasive carcinoma (BRCA), breast invasive carcinoma-luminalA (BRCA-LumA), head and neck squamous cell carcinoma (HNSC), head and neck squamous cell carcinoma with HPV positive (HNSC-HPV(+)), and cancer-associated fibroblasts for the tumors of brain lower grade glioma and stomach adenocarcinoma. Our first pan-cancer study offers a relatively comprehensive understanding of the roles of HK2 in different tumors.
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spelling pubmed-96371502022-11-07 A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors Li, Ruiqi Mei, Shuchong Ding, Qiang Wang, Qingming Yu, Li Zi, Fuming Sci Rep Article More and more evidence show that HK2 is closely related to tumors. But no pan-cancer analysis is available. This paper aimed to explore the potential roles of HK2 across thirty-three tumors based on the datasets of the cancer genome Atlas (TCGA) and gene expression omnibus. HK2 is highly expressed in most tumors and related to the progression of some tumors. HK2 expression was associated with the infiltration of T follicular helper cells for the TCGA tumors of uveal melanoma, breast invasive carcinoma (BRCA), breast invasive carcinoma-luminalA (BRCA-LumA), head and neck squamous cell carcinoma (HNSC), head and neck squamous cell carcinoma with HPV positive (HNSC-HPV(+)), and cancer-associated fibroblasts for the tumors of brain lower grade glioma and stomach adenocarcinoma. Our first pan-cancer study offers a relatively comprehensive understanding of the roles of HK2 in different tumors. Nature Publishing Group UK 2022-11-05 /pmc/articles/PMC9637150/ /pubmed/36335239 http://dx.doi.org/10.1038/s41598-022-23598-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Li, Ruiqi
Mei, Shuchong
Ding, Qiang
Wang, Qingming
Yu, Li
Zi, Fuming
A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors
title A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors
title_full A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors
title_fullStr A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors
title_full_unstemmed A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors
title_short A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors
title_sort pan-cancer analysis of the role of hexokinase ii (hk2) in human tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637150/
https://www.ncbi.nlm.nih.gov/pubmed/36335239
http://dx.doi.org/10.1038/s41598-022-23598-8
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