Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas

Recurrence is frequent in pediatric ependymoma (EPN). Our longitudinal integrated analysis of 30 patient-matched repeated relapses (3.67 ± 1.76 times) over 13 years (5.8 ± 3.8) reveals stable molecular subtypes (RELA and PFA) and convergent DNA methylation reprogramming during serial relapses accomp...

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Detalles Bibliográficos
Autores principales: Zhao, Sibo, Li, Jia, Zhang, Huiyuan, Qi, Lin, Du, Yuchen, Kogiso, Mari, Braun, Frank K., Xiao, Sophie, Huang, Yulun, Li, Jianfang, Teo, Wan-Yee, Lindsay, Holly, Baxter, Patricia, Su, Jack M. F., Adesina, Adekunle, Laczik, Miklós, Genevini, Paola, Veillard, Anne-Clemence, Schvartzman, Sol, Berguet, Geoffrey, Ding, Shi-Rong, Du, Liping, Stephan, Clifford, Yang, Jianhua, Davies, Peter J. A., Lu, Xinyan, Chintagumpala, Murali, Parsons, Donald William, Perlaky, Laszlo, Xia, Yun-Fei, Man, Tsz-Kwong, Huang, Yun, Sun, Deqiang, Li, Xiao-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637194/
https://www.ncbi.nlm.nih.gov/pubmed/36335125
http://dx.doi.org/10.1038/s41467-022-34514-z

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