Fatal Manifestations of Methotrexate Overdose in Case of Psoriasis Due to Dosing Error

For more than 50 years, methotrexate (MTX), when used in low doses, has been one of the most commonly used drugs in the treatment of psoriasis. It has immunosuppressive as well as anti-inflammatory properties. Pancytopenia, hepatic dysfunction, respiratory toxicity, and acute renal failure are some...

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Detalles Bibliográficos
Autores principales: Nimkar, Shubham V, Yelne, Pallavi, Gaidhane, Shilpa A, Acharya, Sourya, Kumar, Sunil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637408/
https://www.ncbi.nlm.nih.gov/pubmed/36381811
http://dx.doi.org/10.7759/cureus.30041
Descripción
Sumario:For more than 50 years, methotrexate (MTX), when used in low doses, has been one of the most commonly used drugs in the treatment of psoriasis. It has immunosuppressive as well as anti-inflammatory properties. Pancytopenia, hepatic dysfunction, respiratory toxicity, and acute renal failure are some of the reported side effects. This is a case study of a patient who had developed florid symptoms of methotrexate toxicity as a result of erroneous overdosing of methotrexate, which was given to her for psoriasis management.

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