Fatal Manifestations of Methotrexate Overdose in Case of Psoriasis Due to Dosing Error

For more than 50 years, methotrexate (MTX), when used in low doses, has been one of the most commonly used drugs in the treatment of psoriasis. It has immunosuppressive as well as anti-inflammatory properties. Pancytopenia, hepatic dysfunction, respiratory toxicity, and acute renal failure are some...

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Autores principales: Nimkar, Shubham V, Yelne, Pallavi, Gaidhane, Shilpa A, Acharya, Sourya, Kumar, Sunil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637408/
https://www.ncbi.nlm.nih.gov/pubmed/36381811
http://dx.doi.org/10.7759/cureus.30041
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author Nimkar, Shubham V
Yelne, Pallavi
Gaidhane, Shilpa A
Acharya, Sourya
Kumar, Sunil
author_facet Nimkar, Shubham V
Yelne, Pallavi
Gaidhane, Shilpa A
Acharya, Sourya
Kumar, Sunil
author_sort Nimkar, Shubham V
collection PubMed
description For more than 50 years, methotrexate (MTX), when used in low doses, has been one of the most commonly used drugs in the treatment of psoriasis. It has immunosuppressive as well as anti-inflammatory properties. Pancytopenia, hepatic dysfunction, respiratory toxicity, and acute renal failure are some of the reported side effects. This is a case study of a patient who had developed florid symptoms of methotrexate toxicity as a result of erroneous overdosing of methotrexate, which was given to her for psoriasis management.
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spelling pubmed-96374082022-11-14 Fatal Manifestations of Methotrexate Overdose in Case of Psoriasis Due to Dosing Error Nimkar, Shubham V Yelne, Pallavi Gaidhane, Shilpa A Acharya, Sourya Kumar, Sunil Cureus Internal Medicine For more than 50 years, methotrexate (MTX), when used in low doses, has been one of the most commonly used drugs in the treatment of psoriasis. It has immunosuppressive as well as anti-inflammatory properties. Pancytopenia, hepatic dysfunction, respiratory toxicity, and acute renal failure are some of the reported side effects. This is a case study of a patient who had developed florid symptoms of methotrexate toxicity as a result of erroneous overdosing of methotrexate, which was given to her for psoriasis management. Cureus 2022-10-07 /pmc/articles/PMC9637408/ /pubmed/36381811 http://dx.doi.org/10.7759/cureus.30041 Text en Copyright © 2022, Nimkar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Nimkar, Shubham V
Yelne, Pallavi
Gaidhane, Shilpa A
Acharya, Sourya
Kumar, Sunil
Fatal Manifestations of Methotrexate Overdose in Case of Psoriasis Due to Dosing Error
title Fatal Manifestations of Methotrexate Overdose in Case of Psoriasis Due to Dosing Error
title_full Fatal Manifestations of Methotrexate Overdose in Case of Psoriasis Due to Dosing Error
title_fullStr Fatal Manifestations of Methotrexate Overdose in Case of Psoriasis Due to Dosing Error
title_full_unstemmed Fatal Manifestations of Methotrexate Overdose in Case of Psoriasis Due to Dosing Error
title_short Fatal Manifestations of Methotrexate Overdose in Case of Psoriasis Due to Dosing Error
title_sort fatal manifestations of methotrexate overdose in case of psoriasis due to dosing error
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637408/
https://www.ncbi.nlm.nih.gov/pubmed/36381811
http://dx.doi.org/10.7759/cureus.30041
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