Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx

INTRODUCTIONS: Excessive mechanical stress is closely associated with cell death in various conditions. Exposure of chondrocytes to excessive mechanical loading leads to a catabolic response as well as exaggerated cell death. Ferroptosis is a recently identified form of cell death during cell aging...

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Detalles Bibliográficos
Autores principales: Wang, Shaoyi, Li, Weiwei, Zhang, Pengfei, Wang, Zihao, Ma, Xiaoyuan, Liu, Chuanju, Vasilev, Krasimir, Zhang, Lei, Zhou, Xiaocong, Liu, Liang, Hayball, John, Dong, Shuli, Li, Yuhua, Gao, Yuan, Cheng, Lei, Zhao, Yunpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637484/
https://www.ncbi.nlm.nih.gov/pubmed/36328754
http://dx.doi.org/10.1016/j.jare.2022.01.004

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