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Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options

Coronavirus disease 2019 (COVID-19) outbreak has become a global public health emergency and has led to devastating results. Mounting evidence proposes that the disease causes severe pulmonary involvement and influences different organs, leading to a critical situation named multi-organ failure. It...

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Autores principales: Nazerian, Yasaman, Ghasemi, Mobina, Yassaghi, Younes, Nazerian, Amirhossein, Hashemi, Seyed Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637536/
https://www.ncbi.nlm.nih.gov/pubmed/36379152
http://dx.doi.org/10.1016/j.intimp.2022.109428
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author Nazerian, Yasaman
Ghasemi, Mobina
Yassaghi, Younes
Nazerian, Amirhossein
Hashemi, Seyed Mahmoud
author_facet Nazerian, Yasaman
Ghasemi, Mobina
Yassaghi, Younes
Nazerian, Amirhossein
Hashemi, Seyed Mahmoud
author_sort Nazerian, Yasaman
collection PubMed
description Coronavirus disease 2019 (COVID-19) outbreak has become a global public health emergency and has led to devastating results. Mounting evidence proposes that the disease causes severe pulmonary involvement and influences different organs, leading to a critical situation named multi-organ failure. It is yet to be fully clarified how the disease becomes so deadly in some patients. However, it is proven that a condition called “cytokine storm” is involved in the deterioration of COVID-19. Although beneficial, sustained production of cytokines and overabundance of inflammatory mediators causing cytokine storm can lead to collateral vital organ damages. Furthermore, cytokine storm can cause post-COVID-19 syndrome (PCS), an important cause of morbidity after the acute phase of COVID-19. Herein, we aim to explain the possible pathophysiology mechanisms involved in COVID-19-related cytokine storm and its association with multi-organ failure and PCS. We also discuss the latest advances in finding the potential therapeutic targets to control cytokine storm wishing to answer unmet clinical demands for treatment of COVID-19.
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spelling pubmed-96375362022-11-07 Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options Nazerian, Yasaman Ghasemi, Mobina Yassaghi, Younes Nazerian, Amirhossein Hashemi, Seyed Mahmoud Int Immunopharmacol Article Coronavirus disease 2019 (COVID-19) outbreak has become a global public health emergency and has led to devastating results. Mounting evidence proposes that the disease causes severe pulmonary involvement and influences different organs, leading to a critical situation named multi-organ failure. It is yet to be fully clarified how the disease becomes so deadly in some patients. However, it is proven that a condition called “cytokine storm” is involved in the deterioration of COVID-19. Although beneficial, sustained production of cytokines and overabundance of inflammatory mediators causing cytokine storm can lead to collateral vital organ damages. Furthermore, cytokine storm can cause post-COVID-19 syndrome (PCS), an important cause of morbidity after the acute phase of COVID-19. Herein, we aim to explain the possible pathophysiology mechanisms involved in COVID-19-related cytokine storm and its association with multi-organ failure and PCS. We also discuss the latest advances in finding the potential therapeutic targets to control cytokine storm wishing to answer unmet clinical demands for treatment of COVID-19. Elsevier B.V. 2022-12 2022-11-07 /pmc/articles/PMC9637536/ /pubmed/36379152 http://dx.doi.org/10.1016/j.intimp.2022.109428 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Nazerian, Yasaman
Ghasemi, Mobina
Yassaghi, Younes
Nazerian, Amirhossein
Hashemi, Seyed Mahmoud
Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options
title Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options
title_full Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options
title_fullStr Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options
title_full_unstemmed Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options
title_short Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options
title_sort role of sars-cov-2-induced cytokine storm in multi-organ failure: molecular pathways and potential therapeutic options
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637536/
https://www.ncbi.nlm.nih.gov/pubmed/36379152
http://dx.doi.org/10.1016/j.intimp.2022.109428
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