Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates heparan sulfate biosynthesis and shapes gastric cancer cell motility and invasion

Heparan sulfate (HS) proteoglycans (HSPGs) are abundant glycoconjugates in cells’ glycocalyx and extracellular matrix. By acting as scaffolds for protein–protein interactions, HSPGs modulate extracellular ligand gradients, cell signaling networks, and cell–extracellular matrix crosstalk. Aberrant ex...

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Detalles Bibliográficos
Autores principales: Marques, Catarina, Poças, Juliana, Gomes, Catarina, Faria-Ramos, Isabel, Reis, Celso A., Vivès, Romain R., Magalhães, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637574/
https://www.ncbi.nlm.nih.gov/pubmed/36181793
http://dx.doi.org/10.1016/j.jbc.2022.102546

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