α-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α

α-synucleinopathy is driven by an imbalance of synthesis and degradation of α-synuclein (αSyn), causing a build up of αSyn aggregates and post-translationally modified species, which not only interfere with normal cellular metabolism but also by their secretion propagates the disease. Therefore, a b...

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Detalles Bibliográficos
Autores principales: Borland, Helena, Rasmussen, Izabela, Bjerregaard-Andersen, Kaare, Rasmussen, Michel, Olsen, Anders, Vilhardt, Frederik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637583/
https://www.ncbi.nlm.nih.gov/pubmed/36162505
http://dx.doi.org/10.1016/j.jbc.2022.102531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637583/
https://www.ncbi.nlm.nih.gov/pubmed/36162505
http://dx.doi.org/10.1016/j.jbc.2022.102531

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