Artificial pore blocker acts specifically on voltage-gated potassium channel isoform K(V)1.6

Among voltage-gated potassium channel (K(V)) isoforms, K(V)1.6 is one of the most widespread in the nervous system. However, there are little data concerning its physiological significance, in part due to the scarcity of specific ligands. The known high-affinity ligands of K(V)1.6 lack selectivity,...

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Detalles Bibliográficos
Autores principales: Gigolaev, Andrei M., Lushpa, Vladislav A., Pinheiro-Junior, Ernesto L., Tabakmakher, Valentin M., Peigneur, Steve, Ignatova, Anastasija A., Feofanov, Alexey V., Efremov, Roman G., Mineev, Konstantin S., Tytgat, Jan, Vassilevski, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637586/
https://www.ncbi.nlm.nih.gov/pubmed/36087839
http://dx.doi.org/10.1016/j.jbc.2022.102467

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