Cargando…
Networks of inflammation, depression, and cognition in aging males and females
BACKGROUND: Prioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but res...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637618/ https://www.ncbi.nlm.nih.gov/pubmed/35895279 http://dx.doi.org/10.1007/s40520-022-02198-6 |
_version_ | 1784825226859642880 |
---|---|
author | Chalmers, Rebecca A. Cervin, Matti Choo, Carol Baune, Bernhard T. Trollor, Julian N. Numbers, Katya Sachdev, Perminder S. Brodaty, Henry Kochan, Nicole A. Medvedev, Oleg N. |
author_facet | Chalmers, Rebecca A. Cervin, Matti Choo, Carol Baune, Bernhard T. Trollor, Julian N. Numbers, Katya Sachdev, Perminder S. Brodaty, Henry Kochan, Nicole A. Medvedev, Oleg N. |
author_sort | Chalmers, Rebecca A. |
collection | PubMed |
description | BACKGROUND: Prioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent. AIMS: To explore the interactive network of inflammation, depression and cognition by sex in older people. METHODS: We used novel network analysis to explore the unique associations between inflammatory biomarkers, depression, cognition, and somatic, genetic, and lifestyle risk factors in an older (aged 70–90 years), non-demented, community-dwelling sample from the longitudinal Sydney Memory and Aging Study (N = 916) at baseline and at a two-year follow-up. RESULTS: The networks of biomarkers, depression, cognition, and relevant covariates were significantly different between males and females. A stable negative link between depression and cognition was found in females only; a stable positive association between biomarker interleukin-6 and depression was found in females only; and a stable positive association between biomarker interleukin-8 and alcohol was found in females only. For both males and females, a stable, positive relationship was found between the presence of APOE-ε4 gene and biomarker C-reactive protein; between education and cognition; and between biomarker interleukin-6 and all other biomarkers. CONCLUSIONS: These findings suggest different psychophysiological mechanisms underlie the interactive network of biomarkers, depression and cognition in males and females that should be considered when designing personalized preventive interventions to maintain cognitively healthy aging. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40520-022-02198-6. |
format | Online Article Text |
id | pubmed-9637618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-96376182022-11-08 Networks of inflammation, depression, and cognition in aging males and females Chalmers, Rebecca A. Cervin, Matti Choo, Carol Baune, Bernhard T. Trollor, Julian N. Numbers, Katya Sachdev, Perminder S. Brodaty, Henry Kochan, Nicole A. Medvedev, Oleg N. Aging Clin Exp Res Original Article BACKGROUND: Prioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent. AIMS: To explore the interactive network of inflammation, depression and cognition by sex in older people. METHODS: We used novel network analysis to explore the unique associations between inflammatory biomarkers, depression, cognition, and somatic, genetic, and lifestyle risk factors in an older (aged 70–90 years), non-demented, community-dwelling sample from the longitudinal Sydney Memory and Aging Study (N = 916) at baseline and at a two-year follow-up. RESULTS: The networks of biomarkers, depression, cognition, and relevant covariates were significantly different between males and females. A stable negative link between depression and cognition was found in females only; a stable positive association between biomarker interleukin-6 and depression was found in females only; and a stable positive association between biomarker interleukin-8 and alcohol was found in females only. For both males and females, a stable, positive relationship was found between the presence of APOE-ε4 gene and biomarker C-reactive protein; between education and cognition; and between biomarker interleukin-6 and all other biomarkers. CONCLUSIONS: These findings suggest different psychophysiological mechanisms underlie the interactive network of biomarkers, depression and cognition in males and females that should be considered when designing personalized preventive interventions to maintain cognitively healthy aging. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40520-022-02198-6. Springer International Publishing 2022-07-27 2022 /pmc/articles/PMC9637618/ /pubmed/35895279 http://dx.doi.org/10.1007/s40520-022-02198-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Chalmers, Rebecca A. Cervin, Matti Choo, Carol Baune, Bernhard T. Trollor, Julian N. Numbers, Katya Sachdev, Perminder S. Brodaty, Henry Kochan, Nicole A. Medvedev, Oleg N. Networks of inflammation, depression, and cognition in aging males and females |
title | Networks of inflammation, depression, and cognition in aging males and females |
title_full | Networks of inflammation, depression, and cognition in aging males and females |
title_fullStr | Networks of inflammation, depression, and cognition in aging males and females |
title_full_unstemmed | Networks of inflammation, depression, and cognition in aging males and females |
title_short | Networks of inflammation, depression, and cognition in aging males and females |
title_sort | networks of inflammation, depression, and cognition in aging males and females |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637618/ https://www.ncbi.nlm.nih.gov/pubmed/35895279 http://dx.doi.org/10.1007/s40520-022-02198-6 |
work_keys_str_mv | AT chalmersrebeccaa networksofinflammationdepressionandcognitioninagingmalesandfemales AT cervinmatti networksofinflammationdepressionandcognitioninagingmalesandfemales AT choocarol networksofinflammationdepressionandcognitioninagingmalesandfemales AT baunebernhardt networksofinflammationdepressionandcognitioninagingmalesandfemales AT trollorjuliann networksofinflammationdepressionandcognitioninagingmalesandfemales AT numberskatya networksofinflammationdepressionandcognitioninagingmalesandfemales AT sachdevperminders networksofinflammationdepressionandcognitioninagingmalesandfemales AT brodatyhenry networksofinflammationdepressionandcognitioninagingmalesandfemales AT kochannicolea networksofinflammationdepressionandcognitioninagingmalesandfemales AT medvedevolegn networksofinflammationdepressionandcognitioninagingmalesandfemales |