Regulation of factor V by the anticoagulant protease activated protein C: Influence of the B-domain and TFPIα

Activated protein C (APC) is an important anticoagulant protein that regulates thrombin generation through inactivation of factor V (FV) and activated factor V (FVa). The rate of APC inactivation of FV is slower compared to FVa, although proteolysis occurs at the same sites (Arg(306), Arg(506), and...

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Detalles Bibliográficos
Autores principales: Ayombil, Francis, Petrillo, Teodolinda, Kim, Haein, Camire, Rodney M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637641/
https://www.ncbi.nlm.nih.gov/pubmed/36183835
http://dx.doi.org/10.1016/j.jbc.2022.102558

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