Recombinant thrombomodulin may protect cardiac capillary endothelial glycocalyx through promoting Glypican-1 expression under experimental endotoxemia

INTRODUCTION: Myocardial dysfunction occurs in patients with sepsis due to vascular endothelial injury. Recombinant human thrombomodulin (rhTM) attenuates vascular endothelial injuries through endothelial glycocalyx (eGC) protection. HYPOTHESIS: We hypothesized that rhTM attenuates myocardial dysfun...

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Detalles Bibliográficos
Autores principales: Kakino, Yoshinori, Doi, Tomoaki, Okada, Hideshi, Suzuki, Kodai, Takada, Chihiro, Tomita, Hiroyuki, Asano, Hirotaka, Kano, Soichiro, Wakayama, Yugo, Okuda, Tomoki, Fukuda, Hirotsugu, Nishio, Ayane, Kawasaki, Yuki, Kuroda, Ayumi, Shimada, Takuto, Takashima, Shigeo, Suzuki, Keiko, Yoshimura, Genki, Kamidani, Ryo, Yasuda, Ryu, Fukuta, Tetsuya, Kitagawa, Yuichiro, Okamoto, Haruka, Miyake, Takahito, Suzuki, Akio, Yoshida, Takahiro, Tetsuka, Nobuyuki, Yoshida, Shozo, Ogura, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637643/
https://www.ncbi.nlm.nih.gov/pubmed/36353180
http://dx.doi.org/10.1016/j.heliyon.2022.e11262

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