Novel insights into the origin and development of CNS macrophage subsets

The central nervous system (CNS) hosts a variety of immune cells, including two distinct macrophage populations: microglia are found in the parenchyma, whereas CNS‐associated macrophages (CAMs) cover the CNS interfaces, such as the perivascular spaces, the meninges and the choroid plexus. Recent stu...

Descripción completa

Detalles Bibliográficos
Autores principales: Masuda, Takahiro, Amann, Lukas, Prinz, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637656/
https://www.ncbi.nlm.nih.gov/pubmed/36336786
http://dx.doi.org/10.1002/ctm2.1096
_version_ 1784825234997641216
author Masuda, Takahiro
Amann, Lukas
Prinz, Marco
author_facet Masuda, Takahiro
Amann, Lukas
Prinz, Marco
author_sort Masuda, Takahiro
collection PubMed
description The central nervous system (CNS) hosts a variety of immune cells, including two distinct macrophage populations: microglia are found in the parenchyma, whereas CNS‐associated macrophages (CAMs) cover the CNS interfaces, such as the perivascular spaces, the meninges and the choroid plexus. Recent studies have given novel insights into the nature of CAMs as compared to microglia. In this mini‐review, we summarise the current knowledge about the ontogenetic relationship and the underlying mechanism for the establishment of CNS macrophages during development.
format Online
Article
Text
id pubmed-9637656
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-96376562022-11-14 Novel insights into the origin and development of CNS macrophage subsets Masuda, Takahiro Amann, Lukas Prinz, Marco Clin Transl Med Reviews The central nervous system (CNS) hosts a variety of immune cells, including two distinct macrophage populations: microglia are found in the parenchyma, whereas CNS‐associated macrophages (CAMs) cover the CNS interfaces, such as the perivascular spaces, the meninges and the choroid plexus. Recent studies have given novel insights into the nature of CAMs as compared to microglia. In this mini‐review, we summarise the current knowledge about the ontogenetic relationship and the underlying mechanism for the establishment of CNS macrophages during development. John Wiley and Sons Inc. 2022-11-06 /pmc/articles/PMC9637656/ /pubmed/36336786 http://dx.doi.org/10.1002/ctm2.1096 Text en © 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Masuda, Takahiro
Amann, Lukas
Prinz, Marco
Novel insights into the origin and development of CNS macrophage subsets
title Novel insights into the origin and development of CNS macrophage subsets
title_full Novel insights into the origin and development of CNS macrophage subsets
title_fullStr Novel insights into the origin and development of CNS macrophage subsets
title_full_unstemmed Novel insights into the origin and development of CNS macrophage subsets
title_short Novel insights into the origin and development of CNS macrophage subsets
title_sort novel insights into the origin and development of cns macrophage subsets
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637656/
https://www.ncbi.nlm.nih.gov/pubmed/36336786
http://dx.doi.org/10.1002/ctm2.1096
work_keys_str_mv AT masudatakahiro novelinsightsintotheoriginanddevelopmentofcnsmacrophagesubsets
AT amannlukas novelinsightsintotheoriginanddevelopmentofcnsmacrophagesubsets
AT prinzmarco novelinsightsintotheoriginanddevelopmentofcnsmacrophagesubsets

Ejemplares similares