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Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis

PURPOSE: To quantitatively assess the angiographic features of uveitis associated with sarcoidosis on ultra-widefield fluorescein angiography (UWFA) and determine their correlations with clinical features. DESIGN: A retrospective cohort study. METHODS: Sixty-four eyes (64 patients) with sarcoidosis...

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Autores principales: Suh, Hyun, Lee, Anna, Ra, Ho, Lee, Jun Hyuck, Baek, Jiwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637674/
https://www.ncbi.nlm.nih.gov/pubmed/36353160
http://dx.doi.org/10.1016/j.heliyon.2022.e11218
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author Suh, Hyun
Lee, Anna
Ra, Ho
Lee, Jun Hyuck
Baek, Jiwon
author_facet Suh, Hyun
Lee, Anna
Ra, Ho
Lee, Jun Hyuck
Baek, Jiwon
author_sort Suh, Hyun
collection PubMed
description PURPOSE: To quantitatively assess the angiographic features of uveitis associated with sarcoidosis on ultra-widefield fluorescein angiography (UWFA) and determine their correlations with clinical features. DESIGN: A retrospective cohort study. METHODS: Sixty-four eyes (64 patients) with sarcoidosis uveitis were included. On UWFA, presence of vasculitis, macular leakage, and optic disc leakage were assessed and features including peripheral ischemic area, vascular leakage area, and punched out lesions were quantitatively analyzed using FIJI (ImageJ2) and correlated with clinical features. RESULTS: The mean peripheral ischemic area and leakage area were 0.0419 ± 0.113% and 0.0333 ± 0.0287% of the total retinal area, respectively. Macular and optic disc leakage were present in 18.8% and 59.4% of eyes, respectively. The average number of punched out lesions was 10.02 ± 21.95. Those changes were most abundant in the inferotemporal area. The presence of disc leakage correlated with all the other UWFA parameters (all r ≥ 0.260; all P ≤ 0.038). The leakage area correlated with vitreous cells, baseline and 6-month logMAR visual acuity, steroid dose and duration, erythrocyte sedimentation rate, and C-reactive protein (r = 0.472, 0.288, 0.321, 0.374, 0.250, 0.251, and 0.277; all P ≤ 0.46). CONCLUSIONS: This study quantitatively analyzed UWFA data in sarcoidosis uveitis. Angiographic changes were most frequent in the inferotemporal area. UWFA parameters correlated with one another and clinical variables. These quantitative imaging results warrant a subjective analysis of sarcoidosis uveitis.
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spelling pubmed-96376742022-11-08 Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis Suh, Hyun Lee, Anna Ra, Ho Lee, Jun Hyuck Baek, Jiwon Heliyon Research Article PURPOSE: To quantitatively assess the angiographic features of uveitis associated with sarcoidosis on ultra-widefield fluorescein angiography (UWFA) and determine their correlations with clinical features. DESIGN: A retrospective cohort study. METHODS: Sixty-four eyes (64 patients) with sarcoidosis uveitis were included. On UWFA, presence of vasculitis, macular leakage, and optic disc leakage were assessed and features including peripheral ischemic area, vascular leakage area, and punched out lesions were quantitatively analyzed using FIJI (ImageJ2) and correlated with clinical features. RESULTS: The mean peripheral ischemic area and leakage area were 0.0419 ± 0.113% and 0.0333 ± 0.0287% of the total retinal area, respectively. Macular and optic disc leakage were present in 18.8% and 59.4% of eyes, respectively. The average number of punched out lesions was 10.02 ± 21.95. Those changes were most abundant in the inferotemporal area. The presence of disc leakage correlated with all the other UWFA parameters (all r ≥ 0.260; all P ≤ 0.038). The leakage area correlated with vitreous cells, baseline and 6-month logMAR visual acuity, steroid dose and duration, erythrocyte sedimentation rate, and C-reactive protein (r = 0.472, 0.288, 0.321, 0.374, 0.250, 0.251, and 0.277; all P ≤ 0.46). CONCLUSIONS: This study quantitatively analyzed UWFA data in sarcoidosis uveitis. Angiographic changes were most frequent in the inferotemporal area. UWFA parameters correlated with one another and clinical variables. These quantitative imaging results warrant a subjective analysis of sarcoidosis uveitis. Elsevier 2022-10-22 /pmc/articles/PMC9637674/ /pubmed/36353160 http://dx.doi.org/10.1016/j.heliyon.2022.e11218 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Suh, Hyun
Lee, Anna
Ra, Ho
Lee, Jun Hyuck
Baek, Jiwon
Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis
title Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis
title_full Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis
title_fullStr Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis
title_full_unstemmed Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis
title_short Quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis
title_sort quantitative analysis of ultra-widefield fluorescein angiography in uveitis associated with sarcoidosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637674/
https://www.ncbi.nlm.nih.gov/pubmed/36353160
http://dx.doi.org/10.1016/j.heliyon.2022.e11218
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