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Attenuation correction for PET/MRI to measure tracer activity surrounding total knee arthroplasty
BACKGROUND: Positron emission tomography (PET) in combination with magnetic resonance imaging (MRI) could allow inflammatory complications near total knee arthroplasty (TKA) to be studied early in their development. However, attenuation of the PET signal by the metal TKA implants imparts substantial...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637681/ https://www.ncbi.nlm.nih.gov/pubmed/36336748 http://dx.doi.org/10.1186/s41824-022-00152-3 |
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author | Bourdon, Caleigh E. Koudys, Zachary J. Lanting, Brent A. Appleton, C. Thomas Thiessen, Jonathan D. Teeter, Matthew G. |
author_facet | Bourdon, Caleigh E. Koudys, Zachary J. Lanting, Brent A. Appleton, C. Thomas Thiessen, Jonathan D. Teeter, Matthew G. |
author_sort | Bourdon, Caleigh E. |
collection | PubMed |
description | BACKGROUND: Positron emission tomography (PET) in combination with magnetic resonance imaging (MRI) could allow inflammatory complications near total knee arthroplasty (TKA) to be studied early in their development. However, attenuation of the PET signal by the metal TKA implants imparts substantial error into measurements of tracer activity, and conventional MR-based attenuation correction (AC) methods have large signal voids in the vicinity of metal implants. PURPOSE: To evaluate a segmentation-based AC approach to measure tracer uptake from PET/MRI scans near TKA implants. METHODS: A TKA implant (Triathlon, Stryker, Mahwah, USA) was implanted into a cadaver. Four vials were filled with [(18)F]fluorodeoxyglucose with known activity concentration (4.68 MBq total, 0.76 MBq/mL) and inserted into the knee. Images of the knee were acquired using a 3T PET/MRI system (Biograph mMR, Siemens Healthcare, Erlangen, Germany). Models of the implant components were registered to the MR data using rigid-body transformations and the other tissue classes were manually segmented. These segments were used to create the segmentation-based map and complete the AC. Percentage error of the resulting measured activities was calculated by comparing the measured and known amounts of activity in each vial. RESULTS: The original AC resulted in a percentage error of 64.1% from the known total activity. Errors in the individual vial activities ranged from 40.2 to 82.7%. Using the new segmentation-based AC, the percentage error of the total activity decreased to 3.55%. Errors in the individual vials were less than 15%. CONCLUSIONS: The segmentation-based AC technique dramatically reduced the error in activity measurements that result from PET signal attenuation by the metal TKA implant. This approach may be useful to enhance the reliability of PET/MRI measurements for numerous applications. |
format | Online Article Text |
id | pubmed-9637681 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-96376812022-11-08 Attenuation correction for PET/MRI to measure tracer activity surrounding total knee arthroplasty Bourdon, Caleigh E. Koudys, Zachary J. Lanting, Brent A. Appleton, C. Thomas Thiessen, Jonathan D. Teeter, Matthew G. Eur J Hybrid Imaging Original Article BACKGROUND: Positron emission tomography (PET) in combination with magnetic resonance imaging (MRI) could allow inflammatory complications near total knee arthroplasty (TKA) to be studied early in their development. However, attenuation of the PET signal by the metal TKA implants imparts substantial error into measurements of tracer activity, and conventional MR-based attenuation correction (AC) methods have large signal voids in the vicinity of metal implants. PURPOSE: To evaluate a segmentation-based AC approach to measure tracer uptake from PET/MRI scans near TKA implants. METHODS: A TKA implant (Triathlon, Stryker, Mahwah, USA) was implanted into a cadaver. Four vials were filled with [(18)F]fluorodeoxyglucose with known activity concentration (4.68 MBq total, 0.76 MBq/mL) and inserted into the knee. Images of the knee were acquired using a 3T PET/MRI system (Biograph mMR, Siemens Healthcare, Erlangen, Germany). Models of the implant components were registered to the MR data using rigid-body transformations and the other tissue classes were manually segmented. These segments were used to create the segmentation-based map and complete the AC. Percentage error of the resulting measured activities was calculated by comparing the measured and known amounts of activity in each vial. RESULTS: The original AC resulted in a percentage error of 64.1% from the known total activity. Errors in the individual vial activities ranged from 40.2 to 82.7%. Using the new segmentation-based AC, the percentage error of the total activity decreased to 3.55%. Errors in the individual vials were less than 15%. CONCLUSIONS: The segmentation-based AC technique dramatically reduced the error in activity measurements that result from PET signal attenuation by the metal TKA implant. This approach may be useful to enhance the reliability of PET/MRI measurements for numerous applications. Springer International Publishing 2022-11-07 /pmc/articles/PMC9637681/ /pubmed/36336748 http://dx.doi.org/10.1186/s41824-022-00152-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Bourdon, Caleigh E. Koudys, Zachary J. Lanting, Brent A. Appleton, C. Thomas Thiessen, Jonathan D. Teeter, Matthew G. Attenuation correction for PET/MRI to measure tracer activity surrounding total knee arthroplasty |
title | Attenuation correction for PET/MRI to measure tracer activity surrounding total knee arthroplasty |
title_full | Attenuation correction for PET/MRI to measure tracer activity surrounding total knee arthroplasty |
title_fullStr | Attenuation correction for PET/MRI to measure tracer activity surrounding total knee arthroplasty |
title_full_unstemmed | Attenuation correction for PET/MRI to measure tracer activity surrounding total knee arthroplasty |
title_short | Attenuation correction for PET/MRI to measure tracer activity surrounding total knee arthroplasty |
title_sort | attenuation correction for pet/mri to measure tracer activity surrounding total knee arthroplasty |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637681/ https://www.ncbi.nlm.nih.gov/pubmed/36336748 http://dx.doi.org/10.1186/s41824-022-00152-3 |
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