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ZEB2 haploinsufficient Mowat-Wilson syndrome induced pluripotent stem cells show disrupted GABAergic transcriptional regulation and function

Mowat-Wilson syndrome (MWS) is a severe neurodevelopmental disorder caused by heterozygous variants in the gene encoding transcription factor ZEB2. Affected individuals present with structural brain abnormalities, speech delay and epilepsy. In mice, conditional loss of Zeb2 causes hippocampal degene...

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Detalles Bibliográficos
Autores principales:	Schuster, Jens, Klar, Joakim, Khalfallah, Ayda, Laan, Loora, Hoeber, Jan, Fatima, Ambrin, Sequeira, Velin Marita, Jin, Zhe, Korol, Sergiy V., Huss, Mikael, Nordgren, Ann, Anderlid, Britt Marie, Gallant, Caroline, Birnir, Bryndis, Dahl, Niklas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637781/ https://www.ncbi.nlm.nih.gov/pubmed/36353360 http://dx.doi.org/10.3389/fnmol.2022.988993

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