Conversion of ER, PR, HER2 and Ki-67 and Prognosis in breast cancer metastases to the brain

OBJECTIVE: This study aimed to analyze the expression levels of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 proliferation index in the brain metastatic lesions and primary lesions in Chinese patients with breast cancer brain metasta...

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Autores principales: Jiaxin, Chen, Jinmei, Zhou, Huiqiang, Zhang, Xuexue, Wu, Xiaobo, Wang, Shaohua, Zhang, Yanhong, Tai, Zefei, Jiang, Tao, Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637832/
https://www.ncbi.nlm.nih.gov/pubmed/36353124
http://dx.doi.org/10.3389/fneur.2022.1002173
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author Jiaxin, Chen
Jinmei, Zhou
Huiqiang, Zhang
Xuexue, Wu
Xiaobo, Wang
Shaohua, Zhang
Yanhong, Tai
Zefei, Jiang
Tao, Wang
author_facet Jiaxin, Chen
Jinmei, Zhou
Huiqiang, Zhang
Xuexue, Wu
Xiaobo, Wang
Shaohua, Zhang
Yanhong, Tai
Zefei, Jiang
Tao, Wang
author_sort Jiaxin, Chen
collection PubMed
description OBJECTIVE: This study aimed to analyze the expression levels of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 proliferation index in the brain metastatic lesions and primary lesions in Chinese patients with breast cancer brain metastasis (BCBM) and determine the correlation between their changes and patients' survival. METHODS: A retrospective analysis was performed on patients with BCBM. The clinical characteristic of these patients was collected. The differences in the expression levels of the ER, PR, HER-2, and Ki-67 index between the primary lesions and brain lesions were evaluated, and the association between the differences and survival was analyzed. RESULTS: The conversion rate of anyone receptor (ER, PR, or HER2) between the primary lesions and brain metastatic lesions was 45.0% (18/40), of which the ER inconsistency rate was 25.0%, the PR inconsistency rate was 22.5%, and the HER-2 inconsistency rate was 15.0%, and the receptor conversion resulted in a subtype conversion of 27.5% (11/40). The patients with HER-2 expression discordance between the primary lesions and the brain metastatic lesions had significantly longer survival times (58.9 vs. 26.4 months, P = 0.04) after diagnosis of brain metastases. CONCLUSION: In this study, 45.0% of breast cancer patients developed biomarker-conversion between the primary lesions and brain metastatic lesions, and the differences in the expression levels of the ER, PR, and HER-2, the change in Ki-67 index between the primary lesions and brain lesions may predict patients' survival.
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spelling pubmed-96378322022-11-08 Conversion of ER, PR, HER2 and Ki-67 and Prognosis in breast cancer metastases to the brain Jiaxin, Chen Jinmei, Zhou Huiqiang, Zhang Xuexue, Wu Xiaobo, Wang Shaohua, Zhang Yanhong, Tai Zefei, Jiang Tao, Wang Front Neurol Neurology OBJECTIVE: This study aimed to analyze the expression levels of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 proliferation index in the brain metastatic lesions and primary lesions in Chinese patients with breast cancer brain metastasis (BCBM) and determine the correlation between their changes and patients' survival. METHODS: A retrospective analysis was performed on patients with BCBM. The clinical characteristic of these patients was collected. The differences in the expression levels of the ER, PR, HER-2, and Ki-67 index between the primary lesions and brain lesions were evaluated, and the association between the differences and survival was analyzed. RESULTS: The conversion rate of anyone receptor (ER, PR, or HER2) between the primary lesions and brain metastatic lesions was 45.0% (18/40), of which the ER inconsistency rate was 25.0%, the PR inconsistency rate was 22.5%, and the HER-2 inconsistency rate was 15.0%, and the receptor conversion resulted in a subtype conversion of 27.5% (11/40). The patients with HER-2 expression discordance between the primary lesions and the brain metastatic lesions had significantly longer survival times (58.9 vs. 26.4 months, P = 0.04) after diagnosis of brain metastases. CONCLUSION: In this study, 45.0% of breast cancer patients developed biomarker-conversion between the primary lesions and brain metastatic lesions, and the differences in the expression levels of the ER, PR, and HER-2, the change in Ki-67 index between the primary lesions and brain lesions may predict patients' survival. Frontiers Media S.A. 2022-10-24 /pmc/articles/PMC9637832/ /pubmed/36353124 http://dx.doi.org/10.3389/fneur.2022.1002173 Text en Copyright © 2022 Jiaxin, Jinmei, Huiqiang, Xuexue, Xiaobo, Shaohua, Yanhong, Zefei and Tao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Jiaxin, Chen
Jinmei, Zhou
Huiqiang, Zhang
Xuexue, Wu
Xiaobo, Wang
Shaohua, Zhang
Yanhong, Tai
Zefei, Jiang
Tao, Wang
Conversion of ER, PR, HER2 and Ki-67 and Prognosis in breast cancer metastases to the brain
title Conversion of ER, PR, HER2 and Ki-67 and Prognosis in breast cancer metastases to the brain
title_full Conversion of ER, PR, HER2 and Ki-67 and Prognosis in breast cancer metastases to the brain
title_fullStr Conversion of ER, PR, HER2 and Ki-67 and Prognosis in breast cancer metastases to the brain
title_full_unstemmed Conversion of ER, PR, HER2 and Ki-67 and Prognosis in breast cancer metastases to the brain
title_short Conversion of ER, PR, HER2 and Ki-67 and Prognosis in breast cancer metastases to the brain
title_sort conversion of er, pr, her2 and ki-67 and prognosis in breast cancer metastases to the brain
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637832/
https://www.ncbi.nlm.nih.gov/pubmed/36353124
http://dx.doi.org/10.3389/fneur.2022.1002173
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