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Cerebral blood flow, tau imaging, and memory associations in cognitively unimpaired older adults

OBJECTIVE: Cerebral blood flow (CBF) has been independently linked to cognitive impairment and traditional Alzheimer's disease (AD) pathology (e.g., amyloid-beta [Aβ], tau) in older adults. However, less is known about the possible interactive effects of CBF, Aβ, and tau on memory performance....

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Autores principales: Weigand, Alexandra J., Hamlin, Abbey M., Breton, Jordana, Clark, Alexandra L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637859/
https://www.ncbi.nlm.nih.gov/pubmed/36353072
http://dx.doi.org/10.1016/j.cccb.2022.100153
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author Weigand, Alexandra J.
Hamlin, Abbey M.
Breton, Jordana
Clark, Alexandra L.
author_facet Weigand, Alexandra J.
Hamlin, Abbey M.
Breton, Jordana
Clark, Alexandra L.
author_sort Weigand, Alexandra J.
collection PubMed
description OBJECTIVE: Cerebral blood flow (CBF) has been independently linked to cognitive impairment and traditional Alzheimer's disease (AD) pathology (e.g., amyloid-beta [Aβ], tau) in older adults. However, less is known about the possible interactive effects of CBF, Aβ, and tau on memory performance. The present study examined whether CBF moderates the effect of Aβ and tau on objective and subjective memory within cognitively unimpaired (CU) older adults. METHODS: Participants included 54 predominately white CU older adults from the Alzheimer's Disease Neuroimaging Initiative. Multiple linear regression models examined meta-temporal CBF associations with (1) meta-temporal tau PET adjusting for cortical Aβ PET and (2) and cortical Aβ PET adjusting for tau PET. The CBF and tau meta region was an average of 5 distinct temporal lobe regions. CBF interactions with Aβ or tau PET on memory performance were also examined. Covariates for all models included age, sex, education, pulse pressure, APOE-ε4 positivity, and imaging acquisition date differences. RESULTS: CBF was significantly negatively associated with tau PET (t = -2.16, p = .04) but not Aβ PET (t = 0.98, p = .33). Results revealed a CBF by tau PET interaction such that there was a stronger effect of tau PET on objective (t = 2.51, p = .02) and subjective (t = -2.67, p = .01) memory outcomes among individuals with lower levels of CBF. CONCLUSIONS: Cerebrovascular and tau pathologies may interact to influence cognitive performance. This study highlights the need for future vascular risk interventions, which could offer a scalable and cost-effective method for AD prevention.
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spelling pubmed-96378592022-11-08 Cerebral blood flow, tau imaging, and memory associations in cognitively unimpaired older adults Weigand, Alexandra J. Hamlin, Abbey M. Breton, Jordana Clark, Alexandra L. Cereb Circ Cogn Behav Article OBJECTIVE: Cerebral blood flow (CBF) has been independently linked to cognitive impairment and traditional Alzheimer's disease (AD) pathology (e.g., amyloid-beta [Aβ], tau) in older adults. However, less is known about the possible interactive effects of CBF, Aβ, and tau on memory performance. The present study examined whether CBF moderates the effect of Aβ and tau on objective and subjective memory within cognitively unimpaired (CU) older adults. METHODS: Participants included 54 predominately white CU older adults from the Alzheimer's Disease Neuroimaging Initiative. Multiple linear regression models examined meta-temporal CBF associations with (1) meta-temporal tau PET adjusting for cortical Aβ PET and (2) and cortical Aβ PET adjusting for tau PET. The CBF and tau meta region was an average of 5 distinct temporal lobe regions. CBF interactions with Aβ or tau PET on memory performance were also examined. Covariates for all models included age, sex, education, pulse pressure, APOE-ε4 positivity, and imaging acquisition date differences. RESULTS: CBF was significantly negatively associated with tau PET (t = -2.16, p = .04) but not Aβ PET (t = 0.98, p = .33). Results revealed a CBF by tau PET interaction such that there was a stronger effect of tau PET on objective (t = 2.51, p = .02) and subjective (t = -2.67, p = .01) memory outcomes among individuals with lower levels of CBF. CONCLUSIONS: Cerebrovascular and tau pathologies may interact to influence cognitive performance. This study highlights the need for future vascular risk interventions, which could offer a scalable and cost-effective method for AD prevention. Elsevier 2022-10-27 /pmc/articles/PMC9637859/ /pubmed/36353072 http://dx.doi.org/10.1016/j.cccb.2022.100153 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Weigand, Alexandra J.
Hamlin, Abbey M.
Breton, Jordana
Clark, Alexandra L.
Cerebral blood flow, tau imaging, and memory associations in cognitively unimpaired older adults
title Cerebral blood flow, tau imaging, and memory associations in cognitively unimpaired older adults
title_full Cerebral blood flow, tau imaging, and memory associations in cognitively unimpaired older adults
title_fullStr Cerebral blood flow, tau imaging, and memory associations in cognitively unimpaired older adults
title_full_unstemmed Cerebral blood flow, tau imaging, and memory associations in cognitively unimpaired older adults
title_short Cerebral blood flow, tau imaging, and memory associations in cognitively unimpaired older adults
title_sort cerebral blood flow, tau imaging, and memory associations in cognitively unimpaired older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637859/
https://www.ncbi.nlm.nih.gov/pubmed/36353072
http://dx.doi.org/10.1016/j.cccb.2022.100153
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