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Liver enzyme delayed clearance in rat treated by CSF1 receptor specific antagonist Sotuletinib

Sotuletinib (BLZ945), a CSF1-R specific kinase inhibitor developed for the treatment of Amyotrophic Lateral Sclerosis, induced liver enzyme elevation in absence of hepatocellular lesions in preclinical rat and monkey studies. The monocytic cell family, including Kupffer cells, e.g., the liver-reside...

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Detalles Bibliográficos
Autores principales:	Pognan, François, Buono, Chiara, Couttet, Philippe, Galarneau, Jean-René, Timsit, Yoav, Wolf, Armin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article from the special issue Mechanisms of Repro-Tox edited by Terje Svingen
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637862/ https://www.ncbi.nlm.nih.gov/pubmed/36353522 http://dx.doi.org/10.1016/j.crtox.2022.100091

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