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A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles
BACKGROUND AND AIMS: Overweight or obesity is one of the most prevalent health burdens in companion pets and predisposes subjects to multiple comorbidities and reduced longevity. Dietary management and sufficient exercise are effective options for weight loss but challenged by modern lifestyle and c...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637869/ https://www.ncbi.nlm.nih.gov/pubmed/36352906 http://dx.doi.org/10.3389/fnut.2022.1019615 |
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author | Xue, Jinhua Lu, Yuanyuan Zou, Toujun Shi, Wei Wang, Shuang Cheng, Xu Wan, Juan Chen, Yun Wang, Min Wang, Qingzheng Yang, Xia Ding, Mingxing Qi, Zhili Ding, Yi Hu, Manli Zhang, Xin Li, Hongliang Hu, Yufeng |
author_facet | Xue, Jinhua Lu, Yuanyuan Zou, Toujun Shi, Wei Wang, Shuang Cheng, Xu Wan, Juan Chen, Yun Wang, Min Wang, Qingzheng Yang, Xia Ding, Mingxing Qi, Zhili Ding, Yi Hu, Manli Zhang, Xin Li, Hongliang Hu, Yufeng |
author_sort | Xue, Jinhua |
collection | PubMed |
description | BACKGROUND AND AIMS: Overweight or obesity is one of the most prevalent health burdens in companion pets and predisposes subjects to multiple comorbidities and reduced longevity. Dietary management and sufficient exercise are effective options for weight loss but challenged by modern lifestyle and calorie control-triggered malnutrition. Therefore, this study aimed to develop a formulated obesity control diet characterized by protein- and fiber-rich diet and supplemented with astaxanthin. We systemically evaluated global influences of the designed weight-loss diet on metabolic homeostasis in an obese beagle model. MATERIALS AND METHODS: Beagles were induced for obesity by a 24-week HFD treatment and then included into weight-loss programs. Briefly, obese beagles were randomly assigned to two groups that were fed with a formulated weight-loss diet or control diet, respectively. Body weight and body condition scoring (BCS) were analyzed biweekly. Computed tomography (CT), nuclear magnetic resonance imaging (MRI) measurements, and blood and adipose tissue biopsies were collected at 0 and 8 weeks. Plasma lipids and adipocyte size were also measured after 8 weeks of weight-loss diet feeding. The global influence of the formulated diet on the whole spectrum of gene panels were examined by adipose RNA assays. RESULTS: Twenty-four weeks of continuous HFD feeding significantly induced obesity in beagles, as evidenced by increased body weight, BCS, abdominal fat mass, and serum lipid levels. The obese and metabolic condition of the modeled canine were effectively improved by an 8-week weight-loss diet administration. Importantly, we did not observe any side effects during the weight loss duration. Transcriptional analysis of adipose tissues further supported that a weight-loss diet significantly increased energy metabolism-related pathways and decreased lipid synthesis-related pathways. CONCLUSION: The prescribed weight-loss diet exhibited profound benefits in canine weight management with well safety and palatability. These findings support effective strategies of nutritional management and supplementation approaches for weight control in companion animals. |
format | Online Article Text |
id | pubmed-9637869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96378692022-11-08 A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles Xue, Jinhua Lu, Yuanyuan Zou, Toujun Shi, Wei Wang, Shuang Cheng, Xu Wan, Juan Chen, Yun Wang, Min Wang, Qingzheng Yang, Xia Ding, Mingxing Qi, Zhili Ding, Yi Hu, Manli Zhang, Xin Li, Hongliang Hu, Yufeng Front Nutr Nutrition BACKGROUND AND AIMS: Overweight or obesity is one of the most prevalent health burdens in companion pets and predisposes subjects to multiple comorbidities and reduced longevity. Dietary management and sufficient exercise are effective options for weight loss but challenged by modern lifestyle and calorie control-triggered malnutrition. Therefore, this study aimed to develop a formulated obesity control diet characterized by protein- and fiber-rich diet and supplemented with astaxanthin. We systemically evaluated global influences of the designed weight-loss diet on metabolic homeostasis in an obese beagle model. MATERIALS AND METHODS: Beagles were induced for obesity by a 24-week HFD treatment and then included into weight-loss programs. Briefly, obese beagles were randomly assigned to two groups that were fed with a formulated weight-loss diet or control diet, respectively. Body weight and body condition scoring (BCS) were analyzed biweekly. Computed tomography (CT), nuclear magnetic resonance imaging (MRI) measurements, and blood and adipose tissue biopsies were collected at 0 and 8 weeks. Plasma lipids and adipocyte size were also measured after 8 weeks of weight-loss diet feeding. The global influence of the formulated diet on the whole spectrum of gene panels were examined by adipose RNA assays. RESULTS: Twenty-four weeks of continuous HFD feeding significantly induced obesity in beagles, as evidenced by increased body weight, BCS, abdominal fat mass, and serum lipid levels. The obese and metabolic condition of the modeled canine were effectively improved by an 8-week weight-loss diet administration. Importantly, we did not observe any side effects during the weight loss duration. Transcriptional analysis of adipose tissues further supported that a weight-loss diet significantly increased energy metabolism-related pathways and decreased lipid synthesis-related pathways. CONCLUSION: The prescribed weight-loss diet exhibited profound benefits in canine weight management with well safety and palatability. These findings support effective strategies of nutritional management and supplementation approaches for weight control in companion animals. Frontiers Media S.A. 2022-10-24 /pmc/articles/PMC9637869/ /pubmed/36352906 http://dx.doi.org/10.3389/fnut.2022.1019615 Text en Copyright © 2022 Xue, Lu, Zou, Shi, Wang, Cheng, Wan, Chen, Wang, Wang, Yang, Ding, Qi, Ding, Hu, Zhang, Li and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Xue, Jinhua Lu, Yuanyuan Zou, Toujun Shi, Wei Wang, Shuang Cheng, Xu Wan, Juan Chen, Yun Wang, Min Wang, Qingzheng Yang, Xia Ding, Mingxing Qi, Zhili Ding, Yi Hu, Manli Zhang, Xin Li, Hongliang Hu, Yufeng A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles |
title | A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles |
title_full | A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles |
title_fullStr | A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles |
title_full_unstemmed | A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles |
title_short | A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles |
title_sort | protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637869/ https://www.ncbi.nlm.nih.gov/pubmed/36352906 http://dx.doi.org/10.3389/fnut.2022.1019615 |
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