Inositol phosphorylceramide synthase null Leishmania are viable and virulent in animal infections where salvage of host sphingomyelin predominates

Many pathogens synthesize inositol phosphorylceramide (IPC) as the major sphingolipid (SL), differing from the mammalian host where sphingomyelin (SM) or more complex SLs predominate. The divergence between IPC synthase and mammalian SL synthases has prompted interest as a potential drug target. How...

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Detalles Bibliográficos
Autores principales: Kuhlmann, F. Matthew, Key, Phillip N., Hickerson, Suzanne M., Turk, John, Hsu, Fong-Fu, Beverley, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637897/
https://www.ncbi.nlm.nih.gov/pubmed/36162499
http://dx.doi.org/10.1016/j.jbc.2022.102522

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