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Isocitrate binds to the itaconic acid–responsive LysR-type transcriptional regulator RipR in Salmonella pathogenesis

Macrophages produce itaconic acid in phagosomes in response to bacterial cell wall component lipopolysaccharide to eliminate invading pathogenic bacteria. Itaconic acid competitively inhibits the first enzyme of the bacterial glyoxylate cycle. To overcome itaconic acid stress, bacteria employ the ba...

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Detalles Bibliográficos
Autores principales:	Ki, Nayeon, Kim, Jinshil, Jo, Inseong, Hyun, Yongseong, Ryu, Sangryeol, Ha, Nam-Chul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637912/ https://www.ncbi.nlm.nih.gov/pubmed/36198361 http://dx.doi.org/10.1016/j.jbc.2022.102562

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