Anti-CRISPR protein AcrIF4 inhibits the type I-F CRISPR-Cas surveillance complex by blocking nuclease recruitment and DNA cleavage

The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system provides prokaryotes with protection against mobile genetic elements such as phages. In turn, phages deploy anti-CRISPR (Acr) proteins to evade this immunity. AcrIF4, an Acr targeting the type I-F CRISPR-Cas system, ha...

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Detalles Bibliográficos
Autores principales: Gao, Zhengyu, Zhang, Laixing, Ge, Zihao, Wang, Hao, Yue, Yourun, Jiang, Zhuobing, Wang, Xin, Xu, Chenying, Zhang, Yi, Yang, Maojun, Feng, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637919/
https://www.ncbi.nlm.nih.gov/pubmed/36209819
http://dx.doi.org/10.1016/j.jbc.2022.102575

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