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JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation

Polycomb repressive complex 2 (PRC2) methylates histone H3 lysine 27 (H3K27me3) to maintain gene repression and is essential for cell differentiation. In low-grade endometrial stromal sarcoma (LG-ESS), the PRC2 subunit SUZ12 is often fused with the NuA4/TIP60 subunit JAZF1. We show that JAZF1-SUZ12...

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Detalles Bibliográficos
Autores principales:	Tavares, Manuel, Khandelwal, Garima, Muter, Joanne, Viiri, Keijo, Beltran, Manuel, Brosens, Jan J., Jenner, Richard G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637993/ https://www.ncbi.nlm.nih.gov/pubmed/35649353 http://dx.doi.org/10.1016/j.celrep.2022.110889

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