Xist-mediated silencing requires additive functions of SPEN and Polycomb together with differentiation-dependent recruitment of SmcHD1

X chromosome inactivation (XCI) is mediated by the non-coding RNA Xist, which directs chromatin modification and gene silencing in cis. The RNA binding protein SPEN and associated corepressors have a central role in Xist-mediated gene silencing. Other silencing factors, notably the Polycomb system,...

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Detalles Bibliográficos
Autores principales: Bowness, Joseph S., Nesterova, Tatyana B., Wei, Guifeng, Rodermund, Lisa, Almeida, Mafalda, Coker, Heather, Carter, Emma J., Kadaster, Artun, Brockdorff, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637994/
https://www.ncbi.nlm.nih.gov/pubmed/35584662
http://dx.doi.org/10.1016/j.celrep.2022.110830

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