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Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis

The maintenance of genome stability relies on coordinated control of origin activation and replication fork progression. How the interplay between these processes influences human genetic disease and cancer remains incompletely characterized. Here we show that mouse cells featuring Polε instability...

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Detalles Bibliográficos
Autores principales:	Borel, Valerie, Boeing, Stefan, Van Wietmarschen, Niek, Sridharan, Sriram, Hill, Bethany Rebekah, Ombrato, Luigi, Perez-Lloret, Jimena, Jackson, Deb, Goldstone, Robert, Boulton, Simon J., Nussenzweig, Andre, Bellelli, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637995/ https://www.ncbi.nlm.nih.gov/pubmed/35649380 http://dx.doi.org/10.1016/j.celrep.2022.110871

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