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A cross-sectional study on the effect of dietary zinc intake on the relationship between serum vitamin D(3) and HOMA-IR

INTRODUCTION: Serum vitamin D(3) concentration is associated with the risk of insulin resistance. Zinc has also been reported to be associated with a lower risk of insulin resistance. In addition, zinc is an essential cofactor in the activation of vitamin D(3). However, the effect of dietary zinc in...

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Autores principales: Hu, Biao, Lin, Zheng-yang, Cai, Yuan, Sun, Yue-xin, Yang, Shu-qi, Guo, Jiang-long, Zhang, Shi, Sun, Dong-lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638013/
https://www.ncbi.nlm.nih.gov/pubmed/36352900
http://dx.doi.org/10.3389/fnut.2022.945811
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author Hu, Biao
Lin, Zheng-yang
Cai, Yuan
Sun, Yue-xin
Yang, Shu-qi
Guo, Jiang-long
Zhang, Shi
Sun, Dong-lin
author_facet Hu, Biao
Lin, Zheng-yang
Cai, Yuan
Sun, Yue-xin
Yang, Shu-qi
Guo, Jiang-long
Zhang, Shi
Sun, Dong-lin
author_sort Hu, Biao
collection PubMed
description INTRODUCTION: Serum vitamin D(3) concentration is associated with the risk of insulin resistance. Zinc has also been reported to be associated with a lower risk of insulin resistance. In addition, zinc is an essential cofactor in the activation of vitamin D(3). However, the effect of dietary zinc intake on the relationship between vitamin D(3) and insulin resistance risk has not been fully studied. Therefore, we designed this cross-sectional study to assess the impact of changes in zinc intake on the relationship between vitamin D(3) and insulin resistance risk. STUDY DESIGN AND METHODS: This study analyzed data from the national Health and Nutrition Examination Survey (NHANES) from 2005 to 2018, involving 9,545 participants. Participants were stratified by zinc intake category (low zinc intake <9.58 mg/ day; High zinc intake: ≥9.58 mg/ day). RESULTS: In this cross-sectional study, serum vitamin D(3) levels were independently associated with the risk of insulin resistance in both the low and high Zinc intakes (β: −0.26, 95%Cl: −0.56~0.04 vs. β: −0.56, 95%Cl: −1.01~-0.11). In addition, this association was influenced by different dietary zinc intakes (interaction P < 0.05). CONCLUSIONS: Our results suggest that zinc intake may influence the association between serum vitamin D(3) and the risk of insulin resistance. Further randomized controlled trials are needed to provide more evidence of this finding.
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spelling pubmed-96380132022-11-08 A cross-sectional study on the effect of dietary zinc intake on the relationship between serum vitamin D(3) and HOMA-IR Hu, Biao Lin, Zheng-yang Cai, Yuan Sun, Yue-xin Yang, Shu-qi Guo, Jiang-long Zhang, Shi Sun, Dong-lin Front Nutr Nutrition INTRODUCTION: Serum vitamin D(3) concentration is associated with the risk of insulin resistance. Zinc has also been reported to be associated with a lower risk of insulin resistance. In addition, zinc is an essential cofactor in the activation of vitamin D(3). However, the effect of dietary zinc intake on the relationship between vitamin D(3) and insulin resistance risk has not been fully studied. Therefore, we designed this cross-sectional study to assess the impact of changes in zinc intake on the relationship between vitamin D(3) and insulin resistance risk. STUDY DESIGN AND METHODS: This study analyzed data from the national Health and Nutrition Examination Survey (NHANES) from 2005 to 2018, involving 9,545 participants. Participants were stratified by zinc intake category (low zinc intake <9.58 mg/ day; High zinc intake: ≥9.58 mg/ day). RESULTS: In this cross-sectional study, serum vitamin D(3) levels were independently associated with the risk of insulin resistance in both the low and high Zinc intakes (β: −0.26, 95%Cl: −0.56~0.04 vs. β: −0.56, 95%Cl: −1.01~-0.11). In addition, this association was influenced by different dietary zinc intakes (interaction P < 0.05). CONCLUSIONS: Our results suggest that zinc intake may influence the association between serum vitamin D(3) and the risk of insulin resistance. Further randomized controlled trials are needed to provide more evidence of this finding. Frontiers Media S.A. 2022-10-24 /pmc/articles/PMC9638013/ /pubmed/36352900 http://dx.doi.org/10.3389/fnut.2022.945811 Text en Copyright © 2022 Hu, Lin, Cai, Sun, Yang, Guo, Zhang and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Hu, Biao
Lin, Zheng-yang
Cai, Yuan
Sun, Yue-xin
Yang, Shu-qi
Guo, Jiang-long
Zhang, Shi
Sun, Dong-lin
A cross-sectional study on the effect of dietary zinc intake on the relationship between serum vitamin D(3) and HOMA-IR
title A cross-sectional study on the effect of dietary zinc intake on the relationship between serum vitamin D(3) and HOMA-IR
title_full A cross-sectional study on the effect of dietary zinc intake on the relationship between serum vitamin D(3) and HOMA-IR
title_fullStr A cross-sectional study on the effect of dietary zinc intake on the relationship between serum vitamin D(3) and HOMA-IR
title_full_unstemmed A cross-sectional study on the effect of dietary zinc intake on the relationship between serum vitamin D(3) and HOMA-IR
title_short A cross-sectional study on the effect of dietary zinc intake on the relationship between serum vitamin D(3) and HOMA-IR
title_sort cross-sectional study on the effect of dietary zinc intake on the relationship between serum vitamin d(3) and homa-ir
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638013/
https://www.ncbi.nlm.nih.gov/pubmed/36352900
http://dx.doi.org/10.3389/fnut.2022.945811
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