Cargando…

Primary cutaneous B‐Cell lymphoblastic lymphoma presenting with solitary scalp mass in a female child: A case report and review of the literature

Lymphoblastic lymphoma is a group of non‐Hodgkin lymphomas that account for approximately 2% of all lymphomas. This is a report of a case of a young girl presenting with a solitary scalp mass which was resected. Histopathological examination of the mass along with bone marrow analysis revealed prima...

Descripción completa

Detalles Bibliográficos
Autores principales: Montazer, Fatemeh, Motlagh, Alireza Sanei, Dastgir, Ramtin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638076/
https://www.ncbi.nlm.nih.gov/pubmed/36381035
http://dx.doi.org/10.1002/ccr3.6553
_version_ 1784825327381381120
author Montazer, Fatemeh
Motlagh, Alireza Sanei
Dastgir, Ramtin
author_facet Montazer, Fatemeh
Motlagh, Alireza Sanei
Dastgir, Ramtin
author_sort Montazer, Fatemeh
collection PubMed
description Lymphoblastic lymphoma is a group of non‐Hodgkin lymphomas that account for approximately 2% of all lymphomas. This is a report of a case of a young girl presenting with a solitary scalp mass which was resected. Histopathological examination of the mass along with bone marrow analysis revealed primary cutaneous B‐cell lymphoblastic lymphoma. A nine‐year‐old girl presenting with an asymptomatic erythematous, non‐tender scalp mass present for 12 months was admitted. Skull and brain were intact and devoid of any pathological findings on computed tomography imaging. Systemic examination also showed no evidence of mass lesion in other parts of the body. The lesion was resected and referred for pathological analysis. Microscopic study revealed heavy diffuse dermal and subcutaneous infiltration of monomorphous medium‐sized mononuclear cells, with fine chromatin, scant cytoplasm, and variable nucleoli along with intact epidermis and presence of grenz zone. Tumor cells dissect through the collagen fibers. Extensive mitotic figures and focal infiltration of the skin adnexa are seen. IHC study revealed that TdT, CD79a, CD99, CD45, CD20, and Ki67 markers were positive. According to these findings, a definitive diagnosis of primary cutaneous lymphoblastic lymphoma of B cell type was concluded. The 1‐year follow up after necessary treatment revealed normal findings without traces of recurrence. Lymphoblastic lymphomas (LBL) are a neoplasm of immature B cells belonging to the B‐(B‐LBL) or T‐cell lineage (T‐LBL) that accounts for approximately 2% of all lymphomas. Lymphoblastic lymphoma (LBL) is similar to acute lymphoblastic leukemia (ALL) and the differentiation between these neoplasms is based upon proportion of involvement of lymphoblasts in bone marrow. It has a higher male to female predominance, higher incidence in older children and younger adults, and a relatively higher frequency of CNS and gonadal involvement. The differential diagnosis is based on immunohistochemistry study of B‐cell linage tumor markers. Cutaneous involvement is present in about one third of patients with B‐LBL but rarely in patients with ALL.
format Online
Article
Text
id pubmed-9638076
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-96380762022-11-14 Primary cutaneous B‐Cell lymphoblastic lymphoma presenting with solitary scalp mass in a female child: A case report and review of the literature Montazer, Fatemeh Motlagh, Alireza Sanei Dastgir, Ramtin Clin Case Rep Case Report Lymphoblastic lymphoma is a group of non‐Hodgkin lymphomas that account for approximately 2% of all lymphomas. This is a report of a case of a young girl presenting with a solitary scalp mass which was resected. Histopathological examination of the mass along with bone marrow analysis revealed primary cutaneous B‐cell lymphoblastic lymphoma. A nine‐year‐old girl presenting with an asymptomatic erythematous, non‐tender scalp mass present for 12 months was admitted. Skull and brain were intact and devoid of any pathological findings on computed tomography imaging. Systemic examination also showed no evidence of mass lesion in other parts of the body. The lesion was resected and referred for pathological analysis. Microscopic study revealed heavy diffuse dermal and subcutaneous infiltration of monomorphous medium‐sized mononuclear cells, with fine chromatin, scant cytoplasm, and variable nucleoli along with intact epidermis and presence of grenz zone. Tumor cells dissect through the collagen fibers. Extensive mitotic figures and focal infiltration of the skin adnexa are seen. IHC study revealed that TdT, CD79a, CD99, CD45, CD20, and Ki67 markers were positive. According to these findings, a definitive diagnosis of primary cutaneous lymphoblastic lymphoma of B cell type was concluded. The 1‐year follow up after necessary treatment revealed normal findings without traces of recurrence. Lymphoblastic lymphomas (LBL) are a neoplasm of immature B cells belonging to the B‐(B‐LBL) or T‐cell lineage (T‐LBL) that accounts for approximately 2% of all lymphomas. Lymphoblastic lymphoma (LBL) is similar to acute lymphoblastic leukemia (ALL) and the differentiation between these neoplasms is based upon proportion of involvement of lymphoblasts in bone marrow. It has a higher male to female predominance, higher incidence in older children and younger adults, and a relatively higher frequency of CNS and gonadal involvement. The differential diagnosis is based on immunohistochemistry study of B‐cell linage tumor markers. Cutaneous involvement is present in about one third of patients with B‐LBL but rarely in patients with ALL. John Wiley and Sons Inc. 2022-11-06 /pmc/articles/PMC9638076/ /pubmed/36381035 http://dx.doi.org/10.1002/ccr3.6553 Text en © 2022 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Montazer, Fatemeh
Motlagh, Alireza Sanei
Dastgir, Ramtin
Primary cutaneous B‐Cell lymphoblastic lymphoma presenting with solitary scalp mass in a female child: A case report and review of the literature
title Primary cutaneous B‐Cell lymphoblastic lymphoma presenting with solitary scalp mass in a female child: A case report and review of the literature
title_full Primary cutaneous B‐Cell lymphoblastic lymphoma presenting with solitary scalp mass in a female child: A case report and review of the literature
title_fullStr Primary cutaneous B‐Cell lymphoblastic lymphoma presenting with solitary scalp mass in a female child: A case report and review of the literature
title_full_unstemmed Primary cutaneous B‐Cell lymphoblastic lymphoma presenting with solitary scalp mass in a female child: A case report and review of the literature
title_short Primary cutaneous B‐Cell lymphoblastic lymphoma presenting with solitary scalp mass in a female child: A case report and review of the literature
title_sort primary cutaneous b‐cell lymphoblastic lymphoma presenting with solitary scalp mass in a female child: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638076/
https://www.ncbi.nlm.nih.gov/pubmed/36381035
http://dx.doi.org/10.1002/ccr3.6553
work_keys_str_mv AT montazerfatemeh primarycutaneousbcelllymphoblasticlymphomapresentingwithsolitaryscalpmassinafemalechildacasereportandreviewoftheliterature
AT motlaghalirezasanei primarycutaneousbcelllymphoblasticlymphomapresentingwithsolitaryscalpmassinafemalechildacasereportandreviewoftheliterature
AT dastgirramtin primarycutaneousbcelllymphoblasticlymphomapresentingwithsolitaryscalpmassinafemalechildacasereportandreviewoftheliterature