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Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice

Osteoarthritis, as a common joint disease among middle-aged and elderly people, has many problems, such as diverse pathogenesis, poor prognosis and high recurrence rate, which seriously affects patients’ physical and mental health and reduces their quality of life. At present, the pathogenesis of os...

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Autores principales: Chen, Kun, Zhang, Xianzuo, Li, Zhi, Yuan, Xingshi, Fu, Daijie, Wu, Kerong, Shang, Xifu, Ni, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638109/
https://www.ncbi.nlm.nih.gov/pubmed/36353501
http://dx.doi.org/10.3389/fphar.2022.1058469
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author Chen, Kun
Zhang, Xianzuo
Li, Zhi
Yuan, Xingshi
Fu, Daijie
Wu, Kerong
Shang, Xifu
Ni, Zhe
author_facet Chen, Kun
Zhang, Xianzuo
Li, Zhi
Yuan, Xingshi
Fu, Daijie
Wu, Kerong
Shang, Xifu
Ni, Zhe
author_sort Chen, Kun
collection PubMed
description Osteoarthritis, as a common joint disease among middle-aged and elderly people, has many problems, such as diverse pathogenesis, poor prognosis and high recurrence rate, which seriously affects patients’ physical and mental health and reduces their quality of life. At present, the pathogenesis of osteoarthritis is not completely clear, and the treatment plan is mainly to relieve symptoms and ensure basic quality of life. Therefore, it is particularly urgent to explore the pathogenesis of osteoarthritis. Protein, as organic macromolecule which plays a major role in life activities, plays an important role in the development of disease. Through protein omics, this study found that with the increase of age, excessive sulfur oxidation occurred in endoplasmic reticulum of chondrocytes, which then drove the occurrence of inflammatory reaction, and provided a direction for the follow-up molecular targeted.
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spelling pubmed-96381092022-11-08 Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice Chen, Kun Zhang, Xianzuo Li, Zhi Yuan, Xingshi Fu, Daijie Wu, Kerong Shang, Xifu Ni, Zhe Front Pharmacol Pharmacology Osteoarthritis, as a common joint disease among middle-aged and elderly people, has many problems, such as diverse pathogenesis, poor prognosis and high recurrence rate, which seriously affects patients’ physical and mental health and reduces their quality of life. At present, the pathogenesis of osteoarthritis is not completely clear, and the treatment plan is mainly to relieve symptoms and ensure basic quality of life. Therefore, it is particularly urgent to explore the pathogenesis of osteoarthritis. Protein, as organic macromolecule which plays a major role in life activities, plays an important role in the development of disease. Through protein omics, this study found that with the increase of age, excessive sulfur oxidation occurred in endoplasmic reticulum of chondrocytes, which then drove the occurrence of inflammatory reaction, and provided a direction for the follow-up molecular targeted. Frontiers Media S.A. 2022-10-24 /pmc/articles/PMC9638109/ /pubmed/36353501 http://dx.doi.org/10.3389/fphar.2022.1058469 Text en Copyright © 2022 Chen, Zhang, Li, Yuan, Fu, Wu, Shang and Ni. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Chen, Kun
Zhang, Xianzuo
Li, Zhi
Yuan, Xingshi
Fu, Daijie
Wu, Kerong
Shang, Xifu
Ni, Zhe
Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice
title Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice
title_full Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice
title_fullStr Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice
title_full_unstemmed Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice
title_short Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice
title_sort excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638109/
https://www.ncbi.nlm.nih.gov/pubmed/36353501
http://dx.doi.org/10.3389/fphar.2022.1058469
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