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Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy

An increased burden of premature atrial contractions (PACs) has long been considered a benign phenomenon. However, strong evidence of their involvement in the occurrence of atrial fibrillation (AF), ischemic stroke, and excess mortality suggests the need for management. The central question to be re...

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Autores principales: Guichard, Jean-Baptiste, Guasch, Eduard, Roche, Frederic, Da Costa, Antoine, Mont, Lluís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638131/
https://www.ncbi.nlm.nih.gov/pubmed/36353376
http://dx.doi.org/10.3389/fphys.2022.971691
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author Guichard, Jean-Baptiste
Guasch, Eduard
Roche, Frederic
Da Costa, Antoine
Mont, Lluís
author_facet Guichard, Jean-Baptiste
Guasch, Eduard
Roche, Frederic
Da Costa, Antoine
Mont, Lluís
author_sort Guichard, Jean-Baptiste
collection PubMed
description An increased burden of premature atrial contractions (PACs) has long been considered a benign phenomenon. However, strong evidence of their involvement in the occurrence of atrial fibrillation (AF), ischemic stroke, and excess mortality suggests the need for management. The central question to be resolved is whether increased ectopic atrial rhythm is only a predictor of AF or whether it is a marker of atrial cardiomyopathy and therefore of ischemic stroke. After reviewing the pathophysiology of PACs and its impact on patient prognosis, this mini-review proposes to 1) detail the physiological and clinical elements linking PACs and AF, 2) present the evidence in favor of supraventricular ectopic activity as a marker of cardiomyopathy, and 3) outline the current limitations of this concept and the potential future clinical implications.
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spelling pubmed-96381312022-11-08 Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy Guichard, Jean-Baptiste Guasch, Eduard Roche, Frederic Da Costa, Antoine Mont, Lluís Front Physiol Physiology An increased burden of premature atrial contractions (PACs) has long been considered a benign phenomenon. However, strong evidence of their involvement in the occurrence of atrial fibrillation (AF), ischemic stroke, and excess mortality suggests the need for management. The central question to be resolved is whether increased ectopic atrial rhythm is only a predictor of AF or whether it is a marker of atrial cardiomyopathy and therefore of ischemic stroke. After reviewing the pathophysiology of PACs and its impact on patient prognosis, this mini-review proposes to 1) detail the physiological and clinical elements linking PACs and AF, 2) present the evidence in favor of supraventricular ectopic activity as a marker of cardiomyopathy, and 3) outline the current limitations of this concept and the potential future clinical implications. Frontiers Media S.A. 2022-10-24 /pmc/articles/PMC9638131/ /pubmed/36353376 http://dx.doi.org/10.3389/fphys.2022.971691 Text en Copyright © 2022 Guichard, Guasch, Roche, Da Costa and Mont. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Guichard, Jean-Baptiste
Guasch, Eduard
Roche, Frederic
Da Costa, Antoine
Mont, Lluís
Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy
title Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy
title_full Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy
title_fullStr Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy
title_full_unstemmed Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy
title_short Premature atrial contractions: A predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy
title_sort premature atrial contractions: a predictor of atrial fibrillation and a relevant marker of atrial cardiomyopathy
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638131/
https://www.ncbi.nlm.nih.gov/pubmed/36353376
http://dx.doi.org/10.3389/fphys.2022.971691
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