Cargando…

A Long‐Lasting Skin Protectant Based on CG‐101, a Deep Eutectic Solvent Comprising Choline and Geranic Acid

The COVID‐19 public health crisis has spotlighted the need to improve global hygiene and sanitization. In addition to causing staggering rates of transmission and fatality, COVID‐19 has severely impacted the quality of life and mental health of global citizens. The World Health Organization (WHO) an...

Descripción completa

Detalles Bibliográficos
Autores principales: Shevachman, Marina, Mandal, Abhirup, Gelston, Kevin, Mitragotri, Samir, Joshi, Nitin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638410/
https://www.ncbi.nlm.nih.gov/pubmed/36381128
http://dx.doi.org/10.1002/gch2.202200064
_version_ 1784825408178356224
author Shevachman, Marina
Mandal, Abhirup
Gelston, Kevin
Mitragotri, Samir
Joshi, Nitin
author_facet Shevachman, Marina
Mandal, Abhirup
Gelston, Kevin
Mitragotri, Samir
Joshi, Nitin
author_sort Shevachman, Marina
collection PubMed
description The COVID‐19 public health crisis has spotlighted the need to improve global hygiene and sanitization. In addition to causing staggering rates of transmission and fatality, COVID‐19 has severely impacted the quality of life and mental health of global citizens. The World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) encourage hand hygiene as the first defense against the spread of infection, yet frequent handwashing is often impractical. Widely used ethanol‐based hand sanitizers provide immediate protection against pathogens on the skin, albeit short‐lived, due to their rapid evaporation. Herein, a novel, long‐lasting skin protectant formulated with biocompatible ionic liquid/deep eutectic solvents prepared using generally recognized as safe materials – choline and geranic acid (CG‐101, 5% w/w) – is described. In vitro studies demonstrated that CG‐101 inactivates bacteria and the human coronavirus, hCoV229E, for 4 h after application. Two human clinical studies demonstrate that CG‐101 does not cause skin irritation or sensitization, and a single application of CG‐101 gel imparts skin protection against microbes for significantly longer than conventional 70% ethanol‐based hand sanitizers. These data are the first to indicate that CG‐101 may be a better alternative to alcohol‐based hand sanitizers for long‐term skin protection against infectious diseases.
format Online
Article
Text
id pubmed-9638410
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-96384102022-11-14 A Long‐Lasting Skin Protectant Based on CG‐101, a Deep Eutectic Solvent Comprising Choline and Geranic Acid Shevachman, Marina Mandal, Abhirup Gelston, Kevin Mitragotri, Samir Joshi, Nitin Glob Chall Research Articles The COVID‐19 public health crisis has spotlighted the need to improve global hygiene and sanitization. In addition to causing staggering rates of transmission and fatality, COVID‐19 has severely impacted the quality of life and mental health of global citizens. The World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) encourage hand hygiene as the first defense against the spread of infection, yet frequent handwashing is often impractical. Widely used ethanol‐based hand sanitizers provide immediate protection against pathogens on the skin, albeit short‐lived, due to their rapid evaporation. Herein, a novel, long‐lasting skin protectant formulated with biocompatible ionic liquid/deep eutectic solvents prepared using generally recognized as safe materials – choline and geranic acid (CG‐101, 5% w/w) – is described. In vitro studies demonstrated that CG‐101 inactivates bacteria and the human coronavirus, hCoV229E, for 4 h after application. Two human clinical studies demonstrate that CG‐101 does not cause skin irritation or sensitization, and a single application of CG‐101 gel imparts skin protection against microbes for significantly longer than conventional 70% ethanol‐based hand sanitizers. These data are the first to indicate that CG‐101 may be a better alternative to alcohol‐based hand sanitizers for long‐term skin protection against infectious diseases. John Wiley and Sons Inc. 2022-09-04 /pmc/articles/PMC9638410/ /pubmed/36381128 http://dx.doi.org/10.1002/gch2.202200064 Text en © 2022 The Authors. Global Challenges published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Shevachman, Marina
Mandal, Abhirup
Gelston, Kevin
Mitragotri, Samir
Joshi, Nitin
A Long‐Lasting Skin Protectant Based on CG‐101, a Deep Eutectic Solvent Comprising Choline and Geranic Acid
title A Long‐Lasting Skin Protectant Based on CG‐101, a Deep Eutectic Solvent Comprising Choline and Geranic Acid
title_full A Long‐Lasting Skin Protectant Based on CG‐101, a Deep Eutectic Solvent Comprising Choline and Geranic Acid
title_fullStr A Long‐Lasting Skin Protectant Based on CG‐101, a Deep Eutectic Solvent Comprising Choline and Geranic Acid
title_full_unstemmed A Long‐Lasting Skin Protectant Based on CG‐101, a Deep Eutectic Solvent Comprising Choline and Geranic Acid
title_short A Long‐Lasting Skin Protectant Based on CG‐101, a Deep Eutectic Solvent Comprising Choline and Geranic Acid
title_sort long‐lasting skin protectant based on cg‐101, a deep eutectic solvent comprising choline and geranic acid
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638410/
https://www.ncbi.nlm.nih.gov/pubmed/36381128
http://dx.doi.org/10.1002/gch2.202200064
work_keys_str_mv AT shevachmanmarina alonglastingskinprotectantbasedoncg101adeepeutecticsolventcomprisingcholineandgeranicacid
AT mandalabhirup alonglastingskinprotectantbasedoncg101adeepeutecticsolventcomprisingcholineandgeranicacid
AT gelstonkevin alonglastingskinprotectantbasedoncg101adeepeutecticsolventcomprisingcholineandgeranicacid
AT mitragotrisamir alonglastingskinprotectantbasedoncg101adeepeutecticsolventcomprisingcholineandgeranicacid
AT joshinitin alonglastingskinprotectantbasedoncg101adeepeutecticsolventcomprisingcholineandgeranicacid
AT shevachmanmarina longlastingskinprotectantbasedoncg101adeepeutecticsolventcomprisingcholineandgeranicacid
AT mandalabhirup longlastingskinprotectantbasedoncg101adeepeutecticsolventcomprisingcholineandgeranicacid
AT gelstonkevin longlastingskinprotectantbasedoncg101adeepeutecticsolventcomprisingcholineandgeranicacid
AT mitragotrisamir longlastingskinprotectantbasedoncg101adeepeutecticsolventcomprisingcholineandgeranicacid
AT joshinitin longlastingskinprotectantbasedoncg101adeepeutecticsolventcomprisingcholineandgeranicacid