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Early monocyte response following local ablation in hepatocellular carcinoma

Local ablative therapies are established treatment modalities in the treatment of early- and intermediate-stage hepatocellular carcinoma (HCC). Systemic effects of local ablation on circulating immune cells may contribute to patients’ response. Depending on their activation, myeloid cells are able t...

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Autores principales: Kimm, Melanie A., Kästle, Sophia, Stechele, Matthias M. R., Öcal, Elif, Richter, Lisa, Ümütlü, Muzaffer R., Schinner, Regina, Öcal, Osman, Salvermoser, Lukas, Alunni-Fabbroni, Marianna, Seidensticker, Max, Goldberg, S. Nahum, Ricke, Jens, Wildgruber, Moritz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638411/
https://www.ncbi.nlm.nih.gov/pubmed/36353535
http://dx.doi.org/10.3389/fonc.2022.959987
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author Kimm, Melanie A.
Kästle, Sophia
Stechele, Matthias M. R.
Öcal, Elif
Richter, Lisa
Ümütlü, Muzaffer R.
Schinner, Regina
Öcal, Osman
Salvermoser, Lukas
Alunni-Fabbroni, Marianna
Seidensticker, Max
Goldberg, S. Nahum
Ricke, Jens
Wildgruber, Moritz
author_facet Kimm, Melanie A.
Kästle, Sophia
Stechele, Matthias M. R.
Öcal, Elif
Richter, Lisa
Ümütlü, Muzaffer R.
Schinner, Regina
Öcal, Osman
Salvermoser, Lukas
Alunni-Fabbroni, Marianna
Seidensticker, Max
Goldberg, S. Nahum
Ricke, Jens
Wildgruber, Moritz
author_sort Kimm, Melanie A.
collection PubMed
description Local ablative therapies are established treatment modalities in the treatment of early- and intermediate-stage hepatocellular carcinoma (HCC). Systemic effects of local ablation on circulating immune cells may contribute to patients’ response. Depending on their activation, myeloid cells are able to trigger HCC progression as well as to support anti-tumor immunity. Certain priming of monocytes may already occur while still in the circulation. By using flow cytometry, we analyzed peripheral blood monocyte cell populations from a prospective clinical trial cohort of 21 HCC patients following interstitial brachytherapy (IBT) or radiofrequency ablation (RFA) and investigated alterations in the composition of monocyte subpopulations and monocytic myeloid-derived suppressor cells (mMDSCs) as well as receptors involved in orchestrating monocyte function. We discovered that mMDSC levels increased following both IBT and RFA in virtually all patients. Furthermore, we identified varying alterations in the level of monocyte subpopulations following radiation compared to RFA. (A) Liquid biopsy liquid biopsy of circulating monocytes in the future may provide information on the inflammatory response towards local ablation as part of an orchestrated immune response.
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spelling pubmed-96384112022-11-08 Early monocyte response following local ablation in hepatocellular carcinoma Kimm, Melanie A. Kästle, Sophia Stechele, Matthias M. R. Öcal, Elif Richter, Lisa Ümütlü, Muzaffer R. Schinner, Regina Öcal, Osman Salvermoser, Lukas Alunni-Fabbroni, Marianna Seidensticker, Max Goldberg, S. Nahum Ricke, Jens Wildgruber, Moritz Front Oncol Oncology Local ablative therapies are established treatment modalities in the treatment of early- and intermediate-stage hepatocellular carcinoma (HCC). Systemic effects of local ablation on circulating immune cells may contribute to patients’ response. Depending on their activation, myeloid cells are able to trigger HCC progression as well as to support anti-tumor immunity. Certain priming of monocytes may already occur while still in the circulation. By using flow cytometry, we analyzed peripheral blood monocyte cell populations from a prospective clinical trial cohort of 21 HCC patients following interstitial brachytherapy (IBT) or radiofrequency ablation (RFA) and investigated alterations in the composition of monocyte subpopulations and monocytic myeloid-derived suppressor cells (mMDSCs) as well as receptors involved in orchestrating monocyte function. We discovered that mMDSC levels increased following both IBT and RFA in virtually all patients. Furthermore, we identified varying alterations in the level of monocyte subpopulations following radiation compared to RFA. (A) Liquid biopsy liquid biopsy of circulating monocytes in the future may provide information on the inflammatory response towards local ablation as part of an orchestrated immune response. Frontiers Media S.A. 2022-10-24 /pmc/articles/PMC9638411/ /pubmed/36353535 http://dx.doi.org/10.3389/fonc.2022.959987 Text en Copyright © 2022 Kimm, Kästle, Stechele, Öcal, Richter, Ümütlü, Schinner, Öcal, Salvermoser, Alunni-Fabbroni, Seidensticker, Goldberg, Ricke and Wildgruber https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Kimm, Melanie A.
Kästle, Sophia
Stechele, Matthias M. R.
Öcal, Elif
Richter, Lisa
Ümütlü, Muzaffer R.
Schinner, Regina
Öcal, Osman
Salvermoser, Lukas
Alunni-Fabbroni, Marianna
Seidensticker, Max
Goldberg, S. Nahum
Ricke, Jens
Wildgruber, Moritz
Early monocyte response following local ablation in hepatocellular carcinoma
title Early monocyte response following local ablation in hepatocellular carcinoma
title_full Early monocyte response following local ablation in hepatocellular carcinoma
title_fullStr Early monocyte response following local ablation in hepatocellular carcinoma
title_full_unstemmed Early monocyte response following local ablation in hepatocellular carcinoma
title_short Early monocyte response following local ablation in hepatocellular carcinoma
title_sort early monocyte response following local ablation in hepatocellular carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638411/
https://www.ncbi.nlm.nih.gov/pubmed/36353535
http://dx.doi.org/10.3389/fonc.2022.959987
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