Methotrexate induced pneumonitis – A case report and review of literature

Methotrexate (MTX) is the commonly preferred drug in the treatment of various chronic inflammatory conditions. An uncommon, life-threatening, and fatal event associated with methotrexate use is methotrexate-induced pneumonitis (M-pneu). M-pneu does not correlate with the dosage, duration, or method...

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Detalles Bibliográficos
Autores principales: Vinay, V, Munjal, Sushil K., Verma, Paras, Jain, Sandeep, Yadav, B Ompradeep, Sharma, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638664/
https://www.ncbi.nlm.nih.gov/pubmed/36352932
http://dx.doi.org/10.4103/jfmpc.jfmpc_280_22
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author Vinay, V
Munjal, Sushil K.
Verma, Paras
Jain, Sandeep
Yadav, B Ompradeep
Sharma, Amit
author_facet Vinay, V
Munjal, Sushil K.
Verma, Paras
Jain, Sandeep
Yadav, B Ompradeep
Sharma, Amit
author_sort Vinay, V
collection PubMed
description Methotrexate (MTX) is the commonly preferred drug in the treatment of various chronic inflammatory conditions. An uncommon, life-threatening, and fatal event associated with methotrexate use is methotrexate-induced pneumonitis (M-pneu). M-pneu does not correlate with the dosage, duration, or method of administration. We present a case of M-pneu in a diagnosed rheumatoid arthritis patient after six years of initiation of MTX. Prompt recognition, withdrawal, and supportive therapy have a positive outcome. If untreated, M-pneu has a proven fatality of 17–30% in published cases.
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spelling pubmed-96386642022-11-08 Methotrexate induced pneumonitis – A case report and review of literature Vinay, V Munjal, Sushil K. Verma, Paras Jain, Sandeep Yadav, B Ompradeep Sharma, Amit J Family Med Prim Care Case Report Methotrexate (MTX) is the commonly preferred drug in the treatment of various chronic inflammatory conditions. An uncommon, life-threatening, and fatal event associated with methotrexate use is methotrexate-induced pneumonitis (M-pneu). M-pneu does not correlate with the dosage, duration, or method of administration. We present a case of M-pneu in a diagnosed rheumatoid arthritis patient after six years of initiation of MTX. Prompt recognition, withdrawal, and supportive therapy have a positive outcome. If untreated, M-pneu has a proven fatality of 17–30% in published cases. Wolters Kluwer - Medknow 2022-08 2022-08-30 /pmc/articles/PMC9638664/ /pubmed/36352932 http://dx.doi.org/10.4103/jfmpc.jfmpc_280_22 Text en Copyright: © 2022 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Vinay, V
Munjal, Sushil K.
Verma, Paras
Jain, Sandeep
Yadav, B Ompradeep
Sharma, Amit
Methotrexate induced pneumonitis – A case report and review of literature
title Methotrexate induced pneumonitis – A case report and review of literature
title_full Methotrexate induced pneumonitis – A case report and review of literature
title_fullStr Methotrexate induced pneumonitis – A case report and review of literature
title_full_unstemmed Methotrexate induced pneumonitis – A case report and review of literature
title_short Methotrexate induced pneumonitis – A case report and review of literature
title_sort methotrexate induced pneumonitis – a case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638664/
https://www.ncbi.nlm.nih.gov/pubmed/36352932
http://dx.doi.org/10.4103/jfmpc.jfmpc_280_22
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