The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice

Nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease in the US, partly due to the increasing incidence of metabolic syndrome, obesity, and type 2 diabetes. The roles of bile acids and their receptors, such as the nuclear receptor farnesoid X receptor (FXR) and the G protein-c...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoxin X., Xie, Cen, Libby, Andrew E., Ranjit, Suman, Levi, Jonathan, Myakala, Komuraiah, Bhasin, Kanchan, Jones, Bryce A., Orlicky, David J., Takahashi, Shogo, Dvornikov, Alexander, Kleiner, David E., Hewitt, Stephen M., Adorini, Luciano, Kopp, Jeffrey B., Krausz, Kristopher W., Rosenberg, Avi, McManaman, James L., Robertson, Charles E., Ir, Diana, Frank, Daniel N., Luo, Yuhuan, Gonzalez, Frank J., Gratton, Enrico, Levi, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638804/
https://www.ncbi.nlm.nih.gov/pubmed/36209823
http://dx.doi.org/10.1016/j.jbc.2022.102530

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