Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury

FXR regulates bile acid metabolism, and FXR null (Fxr(−/−)) mice have elevated bile acid levels and progressive liver injury. The inositol-requiring enzyme 1α/X-box binding protein 1 (XBP1) pathway is a protective unfolded protein response pathway activated in response to endoplasmic reticulum stres...

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Detalles Bibliográficos
Autores principales: Liu, Xiaoying, Khalafalla, Mahmoud, Chung, Chuhan, Gindin, Yevgeniy, Hubchak, Susan, LeCuyer, Brian, Kriegermeier, Alyssa, Zhang, Danny, Qiu, Wei, Ding, Xianzhong, Fang, Deyu, Green, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638814/
https://www.ncbi.nlm.nih.gov/pubmed/36162519
http://dx.doi.org/10.1016/j.jlr.2022.100289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638814/
https://www.ncbi.nlm.nih.gov/pubmed/36162519
http://dx.doi.org/10.1016/j.jlr.2022.100289

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