Improvement of the autoimmune phenomenon after treatment of primary hyperparathyroidism: Possible role of dynamics of parathyroid hormone-1-receptor in B-lymphocytes

We report a case of 65-year-old male patient with primary hyperparathyroidism (PHPT) who was admitted to the hospital for autoimmune manifestations (including autoimmune hepatitis and autoantibody development) and exhibited subsequent clinical and paraclinical improvement after parathyroidectomy. By...

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Autores principales: Posso-Osorio, Iván, Rios-Serna, Lady J., Rosero, Angie M., Cárdenas, Diana, Tobón, Gabriel J., Cañas, Carlos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638815/
https://www.ncbi.nlm.nih.gov/pubmed/36353597
http://dx.doi.org/10.1016/j.jtauto.2022.100170
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author Posso-Osorio, Iván
Rios-Serna, Lady J.
Rosero, Angie M.
Cárdenas, Diana
Tobón, Gabriel J.
Cañas, Carlos A.
author_facet Posso-Osorio, Iván
Rios-Serna, Lady J.
Rosero, Angie M.
Cárdenas, Diana
Tobón, Gabriel J.
Cañas, Carlos A.
author_sort Posso-Osorio, Iván
collection PubMed
description We report a case of 65-year-old male patient with primary hyperparathyroidism (PHPT) who was admitted to the hospital for autoimmune manifestations (including autoimmune hepatitis and autoantibody development) and exhibited subsequent clinical and paraclinical improvement after parathyroidectomy. By flow cytometry, the expression of PTH receptor 1 (PTHR1) on B lymphocytes of peripheral blood was documented to be higher than that in healthy controls. After parathyroidectomy, autoimmune manifestations improved, while PTH1R expression on B-lymphocytes increased. The possible role of the dynamics of B-lymphocyte PTHR1 in the development of this autoimmune phenomenon is discussed.
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spelling pubmed-96388152022-11-08 Improvement of the autoimmune phenomenon after treatment of primary hyperparathyroidism: Possible role of dynamics of parathyroid hormone-1-receptor in B-lymphocytes Posso-Osorio, Iván Rios-Serna, Lady J. Rosero, Angie M. Cárdenas, Diana Tobón, Gabriel J. Cañas, Carlos A. J Transl Autoimmun Research paper We report a case of 65-year-old male patient with primary hyperparathyroidism (PHPT) who was admitted to the hospital for autoimmune manifestations (including autoimmune hepatitis and autoantibody development) and exhibited subsequent clinical and paraclinical improvement after parathyroidectomy. By flow cytometry, the expression of PTH receptor 1 (PTHR1) on B lymphocytes of peripheral blood was documented to be higher than that in healthy controls. After parathyroidectomy, autoimmune manifestations improved, while PTH1R expression on B-lymphocytes increased. The possible role of the dynamics of B-lymphocyte PTHR1 in the development of this autoimmune phenomenon is discussed. Elsevier 2022-10-29 /pmc/articles/PMC9638815/ /pubmed/36353597 http://dx.doi.org/10.1016/j.jtauto.2022.100170 Text en © 2022 Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research paper
Posso-Osorio, Iván
Rios-Serna, Lady J.
Rosero, Angie M.
Cárdenas, Diana
Tobón, Gabriel J.
Cañas, Carlos A.
Improvement of the autoimmune phenomenon after treatment of primary hyperparathyroidism: Possible role of dynamics of parathyroid hormone-1-receptor in B-lymphocytes
title Improvement of the autoimmune phenomenon after treatment of primary hyperparathyroidism: Possible role of dynamics of parathyroid hormone-1-receptor in B-lymphocytes
title_full Improvement of the autoimmune phenomenon after treatment of primary hyperparathyroidism: Possible role of dynamics of parathyroid hormone-1-receptor in B-lymphocytes
title_fullStr Improvement of the autoimmune phenomenon after treatment of primary hyperparathyroidism: Possible role of dynamics of parathyroid hormone-1-receptor in B-lymphocytes
title_full_unstemmed Improvement of the autoimmune phenomenon after treatment of primary hyperparathyroidism: Possible role of dynamics of parathyroid hormone-1-receptor in B-lymphocytes
title_short Improvement of the autoimmune phenomenon after treatment of primary hyperparathyroidism: Possible role of dynamics of parathyroid hormone-1-receptor in B-lymphocytes
title_sort improvement of the autoimmune phenomenon after treatment of primary hyperparathyroidism: possible role of dynamics of parathyroid hormone-1-receptor in b-lymphocytes
topic Research paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638815/
https://www.ncbi.nlm.nih.gov/pubmed/36353597
http://dx.doi.org/10.1016/j.jtauto.2022.100170
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