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Assessment of factors and interventions towards therapeutic adherence among persons with non-cystic fibrosis bronchiectasis

Non-cystic fibrosis bronchiectasis (NCFB) is a highly prevalent chronic respiratory disease with substantial burden to both patients and healthcare systems. Persons with NCFB (pwNCFB) are often given complex acute and chronic treatment regimens consisting of medications, airway clearance techniques...

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Detalles Bibliográficos
Autores principales: Thornton, Christina S., Somayaji, Ranjani, Lim, Rachel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638830/
https://www.ncbi.nlm.nih.gov/pubmed/36382236
http://dx.doi.org/10.1183/23120541.00340-2022
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author Thornton, Christina S.
Somayaji, Ranjani
Lim, Rachel K.
author_facet Thornton, Christina S.
Somayaji, Ranjani
Lim, Rachel K.
author_sort Thornton, Christina S.
collection PubMed
description Non-cystic fibrosis bronchiectasis (NCFB) is a highly prevalent chronic respiratory disease with substantial burden to both patients and healthcare systems. Persons with NCFB (pwNCFB) are often given complex acute and chronic treatment regimens consisting of medications, airway clearance techniques and exercise. Accordingly, the high burden in NCFB has contributed to lower therapy adherence, with estimates of 53% to medications, 41% to airway clearance and only 16% to all prescribed therapy. Consequent clinical outcomes from lower adherence include reduced quality of life, accelerated lung function decline and recurrent pulmonary exacerbations. In this narrative review, we explore the impact of multifactorial mechanisms underpinning adherence in NCFB and evaluate the available evidence towards interventions to improve uptake of therapy as demonstrated in other chronic respiratory diseases. A holistic approach, starting with a careful review of patient adherence at regular intervals, may increase the success of multidimensional therapeutic interventions in pwNCFB, but robust ongoing studies are an area of need in this population.
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spelling pubmed-96388302022-11-14 Assessment of factors and interventions towards therapeutic adherence among persons with non-cystic fibrosis bronchiectasis Thornton, Christina S. Somayaji, Ranjani Lim, Rachel K. ERJ Open Res Reviews Non-cystic fibrosis bronchiectasis (NCFB) is a highly prevalent chronic respiratory disease with substantial burden to both patients and healthcare systems. Persons with NCFB (pwNCFB) are often given complex acute and chronic treatment regimens consisting of medications, airway clearance techniques and exercise. Accordingly, the high burden in NCFB has contributed to lower therapy adherence, with estimates of 53% to medications, 41% to airway clearance and only 16% to all prescribed therapy. Consequent clinical outcomes from lower adherence include reduced quality of life, accelerated lung function decline and recurrent pulmonary exacerbations. In this narrative review, we explore the impact of multifactorial mechanisms underpinning adherence in NCFB and evaluate the available evidence towards interventions to improve uptake of therapy as demonstrated in other chronic respiratory diseases. A holistic approach, starting with a careful review of patient adherence at regular intervals, may increase the success of multidimensional therapeutic interventions in pwNCFB, but robust ongoing studies are an area of need in this population. European Respiratory Society 2022-11-07 /pmc/articles/PMC9638830/ /pubmed/36382236 http://dx.doi.org/10.1183/23120541.00340-2022 Text en Copyright ©The authors 2022 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Reviews
Thornton, Christina S.
Somayaji, Ranjani
Lim, Rachel K.
Assessment of factors and interventions towards therapeutic adherence among persons with non-cystic fibrosis bronchiectasis
title Assessment of factors and interventions towards therapeutic adherence among persons with non-cystic fibrosis bronchiectasis
title_full Assessment of factors and interventions towards therapeutic adherence among persons with non-cystic fibrosis bronchiectasis
title_fullStr Assessment of factors and interventions towards therapeutic adherence among persons with non-cystic fibrosis bronchiectasis
title_full_unstemmed Assessment of factors and interventions towards therapeutic adherence among persons with non-cystic fibrosis bronchiectasis
title_short Assessment of factors and interventions towards therapeutic adherence among persons with non-cystic fibrosis bronchiectasis
title_sort assessment of factors and interventions towards therapeutic adherence among persons with non-cystic fibrosis bronchiectasis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638830/
https://www.ncbi.nlm.nih.gov/pubmed/36382236
http://dx.doi.org/10.1183/23120541.00340-2022
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