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IGF1R is a mediator of sex-specific metabolism in mice: Effects of age and high-fat diet

OBJECTIVE: We aimed to investigate the short and long-term metabolic consequences of IGF1R systemic gene deficiency in mice. METHODS: UBC-CreERT2, Igf1r(fl/fl) mutant mice were used to suppress IGF1R signaling in adult tissues by inducing postnatal generalized Igf1r deletion with tamoxifen. Animals...

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Detalles Bibliográficos
Autores principales:	Pérez-Matute, Patricia, López, Icíar P., Íñiguez, María, Recio-Fernández, Emma, Torrens, Raquel, Piñeiro-Hermida, Sergio, Alfaro-Arnedo, Elvira, Chau, Luong, Walz, Christina, Hoeflich, Andreas, Oteo, José A., Pichel, José G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638844/ https://www.ncbi.nlm.nih.gov/pubmed/36353242 http://dx.doi.org/10.3389/fendo.2022.1033208

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