Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses

Anticancer T cells acquire a dysfunctional state characterized by poor effector function and expression of inhibitory receptors, such as PD‐1. Blockade of PD‐1 leads to T cell reinvigoration and is increasingly applied as an effective anticancer treatment. Recent work challenged the commonly held vi...

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Detalles Bibliográficos
Autores principales: Ventura, Pedro M O, Gakovic, Milica, Fischer, Berenice A, Spinelli, Laura, Rota, Giorgia, Pathak, Shalini, Khameneh, Hanif J, Zenobi, Alessandro, Thomson, Sarah, Birchmeier, Walter, Cantrell, Doreen A, Guarda, Greta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638855/
https://www.ncbi.nlm.nih.gov/pubmed/36194675
http://dx.doi.org/10.15252/embr.202255399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638855/
https://www.ncbi.nlm.nih.gov/pubmed/36194675
http://dx.doi.org/10.15252/embr.202255399

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