The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive‐strand RNA viruses

Genome‐wide screens are powerful approaches to unravel regulators of viral infections. Here, a CRISPR screen identifies the RNA helicase DDX42 as an intrinsic antiviral inhibitor of HIV‐1. Depletion of endogenous DDX42 increases HIV‐1 DNA accumulation and infection in cell lines and primary cells. D...

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Detalles Bibliográficos
Autores principales: Bonaventure, Boris, Rebendenne, Antoine, Chaves Valadão, Ana Luiza, Arnaud‐Arnould, Mary, Gracias, Ségolène, Garcia de Gracia, Francisco, McKellar, Joe, Labaronne, Emmanuel, Tauziet, Marine, Vivet‐Boudou, Valérie, Bernard, Eric, Briant, Laurence, Gros, Nathalie, Djilli, Wassila, Courgnaud, Valérie, Parrinello, Hugues, Rialle, Stéphanie, Blaise, Mickaël, Lacroix, Laurent, Lavigne, Marc, Paillart, Jean‐Christophe, Ricci, Emiliano P, Schulz, Reiner, Jouvenet, Nolwenn, Moncorgé, Olivier, Goujon, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638865/
https://www.ncbi.nlm.nih.gov/pubmed/36161446
http://dx.doi.org/10.15252/embr.202154061

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