Anti-CRISPR proteins function through thermodynamic tuning and allosteric regulation of CRISPR RNA-guided surveillance complex

CRISPR RNA-guided detection and degradation of foreign DNA is a dynamic process. Viruses can interfere with this cellular defense by expressing small proteins called anti-CRISPRs. While structural models of anti-CRISPRs bound to their target complex provide static snapshots that inform mechanism, th...

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Detalles Bibliográficos
Autores principales: Patterson, Angela, White, Aidan, Waymire, Elizabeth, Fleck, Sophie, Golden, Sarah, Wilkinson, Royce A, Wiedenheft, Blake, Bothner, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638894/
https://www.ncbi.nlm.nih.gov/pubmed/36215034
http://dx.doi.org/10.1093/nar/gkac841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638894/
https://www.ncbi.nlm.nih.gov/pubmed/36215034
http://dx.doi.org/10.1093/nar/gkac841

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