Cargando…

Anti-CRISPR proteins function through thermodynamic tuning and allosteric regulation of CRISPR RNA-guided surveillance complex

CRISPR RNA-guided detection and degradation of foreign DNA is a dynamic process. Viruses can interfere with this cellular defense by expressing small proteins called anti-CRISPRs. While structural models of anti-CRISPRs bound to their target complex provide static snapshots that inform mechanism, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patterson, Angela, White, Aidan, Waymire, Elizabeth, Fleck, Sophie, Golden, Sarah, Wilkinson, Royce A, Wiedenheft, Blake, Bothner, Brian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638894/ https://www.ncbi.nlm.nih.gov/pubmed/36215034 http://dx.doi.org/10.1093/nar/gkac841

Ejemplares similares

Allosteric activation of CRISPR-Cas12a requires the concerted movement of the bridge helix and helix 1 of the RuvC II domain
por: Wörle, Elisabeth, et al.
Publicado: (2022)

The CRISPR RNA-guided surveillance complex in Escherichia coli accommodates extended RNA spacers
por: Luo, Michelle L., et al.
Publicado: (2016)

CRISPR–Cas9-mediated functional dissection of 3′-UTRs
por: Zhao, Wenxue, et al.
Publicado: (2017)

Role of nucleotide identity in effective CRISPR target escape mutations
por: Künne, Tim, et al.
Publicado: (2018)

Specificity and sensitivity of an RNA targeting type III CRISPR complex coupled with a NucC endonuclease effector
por: Grüschow, Sabine, et al.
Publicado: (2021)

The initiation, propagation and dynamics of CRISPR-SpyCas9 R-loop complex
por: Zeng, Yan, et al.
Publicado: (2018)

Discovery of new type I toxin–antitoxin systems adjacent to CRISPR arrays in Clostridium difficile
por: Maikova, Anna, et al.
Publicado: (2018)

Primed adaptation tolerates extensive structural and size variations of the CRISPR RNA guide in Haloarcula hispanica
por: Gong, Luyao, et al.
Publicado: (2019)

A CRISPR-Cas9–integrase complex generates precise DNA fragments for genome integration
por: Jakhanwal, Shrutee, et al.
Publicado: (2021)

The toxin–antitoxin RNA guards of CRISPR-Cas evolved high specificity through repeat degeneration
por: Cheng, Feiyue, et al.
Publicado: (2022)

Structural insights into target DNA recognition and cleavage by the CRISPR-Cas12c1 system
por: Zhang, Bo, et al.
Publicado: (2022)

DNA targeting by subtype I-D CRISPR–Cas shows type I and type III features
por: Lin, Jinzhong, et al.
Publicado: (2020)

The Rsm (Csr) post-transcriptional regulatory pathway coordinately controls multiple CRISPR–Cas immune systems
por: Campa, Aroa Rey, et al.
Publicado: (2021)

Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins
por: Cheng, Feiyue, et al.
Publicado: (2021)

Allosteric regulation of noncoding RNA function by microRNAs
por: Gorbea, Carlos, et al.
Publicado: (2022)

Nearest neighbor rules for RNA helix folding thermodynamics: improved end effects
por: Zuber, Jeffrey, et al.
Publicado: (2022)

Thermodynamic characterization and nearest neighbor parameters for RNA duplexes under molecular crowding conditions
por: Adams, Miranda S, et al.
Publicado: (2019)

Tuning RNA folding and function through rational design of junction topology
por: Daher, May, et al.
Publicado: (2017)

Fine-tune control of targeted RNAi efficacy by plant artificial small RNAs
por: López-Dolz, Lucio, et al.
Publicado: (2020)

Tuning strand displacement kinetics enables programmable ZTP riboswitch dynamic range in vivo
por: Bushhouse, David Z, et al.
Publicado: (2023)

Modulation of the HIV nucleocapsid dynamics finely tunes its RNA-binding properties during virion genesis
por: Mouhand, Assia, et al.
Publicado: (2018)

Finely tuned conformational dynamics regulate the protective function of the lncRNA MALAT1 triple helix
por: Ageeli, Abeer A, et al.
Publicado: (2019)

Dicer partner protein tunes the length of miRNAs using base-mismatch in the pre-miRNA stem
por: Zhu, Li, et al.
Publicado: (2018)

Reciprocal regulation of hnRNP C and CELF2 through translation and transcription tunes splicing activity in T cells
por: Mallory, Michael J, et al.
Publicado: (2020)

Precise tuning of bacterial translation initiation by non-equilibrium 5′-UTR unfolding observed in single mRNAs
por: Ray, Sujay, et al.
Publicado: (2022)

The domains of yeast eIF4G, eIF4E and the cap fine-tune eIF4A activities through an intricate network of stimulatory and inhibitory effects
por: Krause, Linda, et al.
Publicado: (2022)

DIS3L2 and LSm proteins are involved in the surveillance of Sm ring-deficient snRNAs
por: Roithová, Adriana, et al.
Publicado: (2020)

Surveillance of 3′ mRNA cleavage during transcription termination requires CF IB/Hrp1
por: Li, Jing, et al.
Publicado: (2023)

Exon junction complex-associated multi-adapter RNPS1 nucleates splicing regulatory complexes to maintain transcriptome surveillance
por: Schlautmann, Lena P, et al.
Publicado: (2022)

Activation of viral transcription by stepwise largescale folding of an RNA virus genome
por: Chkuaseli, Tamari, et al.
Publicado: (2020)

Dimerization of an umbravirus RNA genome activates subgenomic mRNA transcription
por: Chkuaseli, Tamari, et al.
Publicado: (2023)

A 212-nt long RNA structure in the Tobacco necrosis virus-D RNA genome is resistant to Xrn degradation
por: Gunawardene, Chaminda D, et al.
Publicado: (2019)

A rationalized definition of general tumor suppressor microRNAs excludes miR-34a
por: Mockly, Sophie, et al.
Publicado: (2022)

Elucidating the distinct contributions of miR-122 in the HCV life cycle reveals insights into virion assembly
por: Rheault, Marylin, et al.
Publicado: (2023)

A dual role of the ribosome-bound chaperones RAC/Ssb in maintaining the fidelity of translation termination
por: Gribling-Burrer, Anne-Sophie, et al.
Publicado: (2019)

LncRNA Meg3 protects endothelial function by regulating the DNA damage response
por: Shihabudeen Haider Ali, Mohamed Sham, et al.
Publicado: (2019)

ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin
por: Tanaka, Iris, et al.
Publicado: (2020)

Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns
por: Olthof, Anouk M, et al.
Publicado: (2021)

RNA processing machineries in Archaea: the 5′-3′ exoribonuclease aRNase J of the β-CASP family is engaged specifically with the helicase ASH-Ski2 and the 3′-5′ exoribonucleolytic RNA exosome machinery
por: Phung, Duy Khanh, et al.
Publicado: (2020)

GNAT toxins evolve toward narrow tRNA target specificities
por: Bikmetov, Dmitry, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_c0r2up8b25d38c9p0h893uo9g6