Molecular basis of cyclic tetra-oligoadenylate processing by small standalone CRISPR-Cas ring nucleases

Standalone ring nucleases are CRISPR ancillary proteins, which downregulate the immune response of Type III CRISPR-Cas systems by cleaving cyclic oligoadenylates (cA) second messengers. Two genes with this function have been found within the Sulfolobus islandicus (Sis) genome. They code for a long p...

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Detalles Bibliográficos
Autores principales: Molina, Rafael, Garcia-Martin, Ricardo, López-Méndez, Blanca, Jensen, Anne Louise Grøn, Ciges-Tomas, J Rafael, Marchena-Hurtado, Javier, Stella, Stefano, Montoya, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638899/
https://www.ncbi.nlm.nih.gov/pubmed/36271789
http://dx.doi.org/10.1093/nar/gkac923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638899/
https://www.ncbi.nlm.nih.gov/pubmed/36271789
http://dx.doi.org/10.1093/nar/gkac923

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