G-quadruplex-guided RNA engineering to modulate CRISPR-based genomic regulation

It is important to develop small moelcule-based methods to modulate gene editing and expression in human cells. The roles of the G-quadruplex (G4) in biological systems have been widely studied. Here, G4-guided RNA engineering is performed to generate guide RNA with G4-forming units (G4-gRNA). We fu...

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Detalles Bibliográficos
Autores principales: Liu, Xingyu, Cui, Shuangyu, Qi, Qianqian, Lei, Huajun, Zhang, Yutong, Shen, Wei, Fu, Fang, Tian, Tian, Zhou, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638906/
https://www.ncbi.nlm.nih.gov/pubmed/36263801
http://dx.doi.org/10.1093/nar/gkac870

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