Catalytically inactive DNA ligase IV promotes DNA repair in living cells

DNA double strand breaks (DSBs) are induced by external genotoxic agents (ionizing radiation or genotoxins) or by internal processes (recombination intermediates in lymphocytes or by replication errors). The DNA ends induced by these genotoxic processes are often not ligatable, requiring potentially...

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Detalles Bibliográficos
Autores principales: Goff, Noah J, Brenière, Manon, Buehl, Christopher J, de Melo, Abinadabe J, Huskova, Hana, Ochi, Takashi, Blundell, Tom L, Mao, Weifeng, Yu, Kefei, Modesti, Mauro, Meek, Katheryn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638927/
https://www.ncbi.nlm.nih.gov/pubmed/36263813
http://dx.doi.org/10.1093/nar/gkac913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638927/
https://www.ncbi.nlm.nih.gov/pubmed/36263813
http://dx.doi.org/10.1093/nar/gkac913

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