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The Mycobacterium tuberculosis Ku C-terminus is a multi-purpose arm for binding DNA and LigD and stimulating ligation

Bacterial non-homologous end joining requires the ligase, LigD and Ku. Ku finds the break site, recruits LigD, and then assists LigD to seal the phosphodiester backbone. Bacterial Ku contains a core domain conserved with eukaryotes but has a unique C-terminus that can be divided into a minimal C-ter...

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Detalles Bibliográficos
Autores principales:	Sowa, Dana J, Warner, Monica M, Tetenych, Andriana, Koechlin, Lucas, Balari, Pardis, Rascon Perez, Jose Pablo, Caba, Cody, Andres, Sara N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638933/ https://www.ncbi.nlm.nih.gov/pubmed/36250639 http://dx.doi.org/10.1093/nar/gkac906

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